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Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals
It is concluded that Cx40 is the constitutive vascular gap junction protein in situ and guarantees cell coupling between cells in the vessel wall and the differentiated distribution of both Cx37 and Cx43 suggests they are involved in more dynamic processes.
Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution.
- E. Verheijck, M. J. van Kempen, M. Veereschild, J. Lurvink, H. Jongsma, L. Bouman
- Biology, MedicineCardiovascular research
- 1 October 2001
This organization of the mouse SA node provides a structural substrate that both shields the nodal area from the hyperpolarizing influence of the atrium and allows fast action potential conduction from the nodAL area into the surrounding atrium.
Differential connexin distribution accommodates cardiac function in different species
- M. J. van Kempen, I. T. Velde, +5 authors W. Lamers
- Biology, MedicineMicroscopy research and technique
- 1 August 1995
It is concluded that Cx40 and Cx43 containing gap junctions appear in the ventricular conduction system from distal to proximal and only after birth, which indicates that terminal differentiation of the conductionSystem occurs unexpectedly late in development.
Gap junctions in human umbilical cord endothelial cells contain multiple connexins.
- H. V. van Rijen, M. J. van Kempen, +4 authors H. Jongsma
- Biology, MedicineThe American journal of physiology
Electrophysiological gap junctional characteristics were determined in cultured HUVEC and HUAEC pairs by use of the dual voltage-clamp technique and, Interestingly, additional conductances of 80-200 pS were measured in HUA EC, possibly partially reflecting activity of channels formed of Cx40, which are more abundant in the cultured arterial endothelial cells.
Immunohistochemical delineation of the conduction system. I: The sinoatrial node.
- P. W. Oosthoek, S. Virágh, A. Mayen, M. J. van Kempen, W. Lamers, A. Moorman
- Biology, MedicineCirculation research
- 1 September 1993
It is hypothesize that the architecture of the periphery of the node is important to prevent silencing of the pacemaking nodal myocytes by the atrium while ensuring a sufficient source loading of the nodalMyocytes.
Endothelial-Specific Deletion of Connexin40 Promotes Atherosclerosis by Increasing CD73-Dependent Leukocyte Adhesion
Cx40-mediated gap junctional communication contributes to a quiescent nonactivated endothelium by propagating adenosine-evoked antiinflammatory signals between endothelial cells, thus accelerating atherosclerosis.
Restricted distribution of connexin40, a gap junctional protein, in mammalian heart.
The results of immunoelectron microscopy carried out with guinea pig atrial tissue showed that epitopes recognized by these antibodies were exclusively associated with gap junctions, and Cx40 is the first connexin demonstrated in this region of the rat conduction system.
Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart.
- M. J. van Kempen, J. Vermeulen, A. Moorman, D. Gros, D. Paul, W. Lamers
- MedicineCardiovascular research
The temporally separate disappearance of Cx40 mRNA from the fetal ventricles implies that left and right ventricularles mature independently with respect to gap-junctional communication, and implies pretranslationally regulated gene expression.
Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells.
Investigation of whether TNF-alpha alters the expression of gap junction proteins (connexins, Cx) between human umbilical vein endothelial cells (HUVEC), thereby changing the extent of intercellular communication, as measured by dye coupling finds a decrease in dye coupling.
Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart.
- M. J. van Kempen, C. Fromaget, D. Gros, A. Moorman, W. Lamers
- Biology, MedicineCirculation research
- 1 June 1991
The results demonstrate that from embryonic day 13 onward, connexin43 becomes detectable immunohistochemically in the myocardium of atria and ventricles, and it remains undetectable in the atrioventricular node and bundle and the proximal part of the ventricular conduction tissue, even in the adult heart.