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Auranofin: Repurposing an Old Drug for a Golden New Age
Drug discovery, development and registration is an expensive and time-consuming process associated with a high failure rate [Pessetto et al. (Mol Cancer Ther 12:1299–1309, 2013), Woodcock and WoosleyExpand
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Regulation of denitrification genes in Neisseria meningitidis by nitric oxide and the repressor NsrR.
The human pathogen Neisseria meningitidis is capable of growth using the denitrification of nitrite to nitrous oxide under microaerobic conditions. This process is catalyzed by two reductases:Expand
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Open Access
The nitric oxide (NO)-sensing repressor NsrR of Neisseria meningitidis has a compact regulon of genes involved in NO synthesis and detoxification.
We have analyzed the extent of regulation by the nitric oxide (NO)-sensitive repressor NsrR from Neisseria meningitidis MC58, using microarray analysis. Target genes that appeared to be regulated byExpand
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Open Access
Gastric Helicobacter Infection Induces Iron Deficiency in the INS-GAS Mouse
There is increasing evidence from clinical and population studies for a role of H. pylori infection in the aetiology of iron deficiency. Rodent models of Helicobacter infection are helpful forExpand
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Open Access
Binding to DNA Protects Neisseria meningitidis Fumarate and Nitrate Reductase Regulator (FNR) from Oxygen*
Here, we report the overexpression, purification, and characterization of the transcriptional activator fumarate and nitrate reductase regulator from the pathogenic bacterium Neisseria meningitidisExpand
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Dual active ionic liquids and organic salts for inhibition of microbially influenced corrosion.
We describe a series of novel compounds designed to combat the bacterial growth that leads to microbially induced corrosion on steel in the marine environment. A synergistic effect of the ionicExpand
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Neisseria meningitidis and Neisseria gonorrhoeae are differently adapted in the regulation of denitrification: single nucleotide polymorphisms that enable species-specific tuning of the
The closely related pathogenic Neisseria species N. meningitidis and N. gonorrhoeae are able to respire in the absence of oxygen, using nitrite as an alternative electron acceptor. aniAExpand
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Cetrimonium Nalidixate as a Multifunctional Inhibitor to Combat Biofilm Formation and Microbiologically Influenced Corrosion
Microbial infection of surfaces and the formation of biofilms is a pervasive problem that appears in diverse fields from medical implants to corrosion of marine structures. We show here, for theExpand
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Repurposing auranofin as a Clostridioides difficile therapeutic.
BACKGROUND Clostridioides difficile (previously Clostridium difficile) is the leading cause of nosocomial, antibiotic-associated diarrhoea worldwide. Currently, the gold standard of treatment for C.Expand
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