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Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin
Apelin peptides have recently been identified to be the endogenous ligands for the G protein‐coupled receptor APJ. However, little is known about the physiological roles of this ligand‐receptorExpand
Comparative immunohistochemical localisation of GABAB1a, GABAB1b and GABAB2 subunits in rat brain, spinal cord and dorsal root ganglion
GABA(B) receptors are G-protein-coupled receptors mediating the slow onset and prolonged synaptic actions of GABA in the CNS. The recent cloning of two genes, GABA(B1) and GABA(B2), has revealed aExpand
Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia
Aberrant glutamatergic neurotransmission may underlie the pathogenesis of schizophrenia and metabotropic glutamate receptors (mGluRs) have been implicated in the disease. We have established theExpand
The expression of GABAB1 and GABAB2 receptor subunits in the cNS differs from that in peripheral tissues
GABA(B) receptors are G-protein-coupled receptors that mediate the slow and prolonged synaptic actions of GABA in the CNS via the modulation of ion channels. Unusually, GABA(B) receptors formExpand
GABAB2 Is Essential for G-Protein Coupling of the GABAB Receptor Heterodimer
GABAB receptors are unique among G-protein-coupled receptors (GPCRs) in their requirement for heterodimerization between two homologous subunits, GABAB1and GABAB2, for functional expression. WhereasExpand
The C-Terminal Domains of the GABAB Receptor Subunits Mediate Intracellular Trafficking But Are Not Required for Receptor Signaling
GABAB receptors are G-protein-coupled receptors that mediate slow synaptic inhibition in the brain and spinal cord. These receptors are heterodimers assembled from GABAB1 and GABAB2 subunits, neitherExpand
Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague–Dawley rats: A locomotor activity and gene induction study
In a putative model of acute phencyclidine (PCP)-induced psychosis we evaluated effects of the drug on locomotor activity (LMA) and immediate early gene (IEG) induction in the rat using two routes ofExpand
Characterization of the Dimerization of Metabotropic Glutamate Receptors Using an N‐Terminal Truncation of mGluR1α
Abstract: The metabotropic glutamate receptor mGluR1α in membranes isolated both from rat brain and from cell lines transfected with cDNA coding for the receptor migrates as a disulphide‐bonded dimerExpand
Reversal of isolation-rearing-induced PPI deficits by an α7 nicotinic receptor agonist
RationaleThe α7 subtype of the nicotinic receptor plays an important role in auditory sensory gating. Schizophrenics show deficient sensory gating and abnormalities in the number and regulation ofExpand
Interactions of the C Terminus of Metabotropic Glutamate Receptor Type 1α with Rat Brain Proteins
Abstract : Metabotropic glutamate receptors (mGluRs) are coupled to G protein second messenger pathways and modulate glutamate neurotransmission in the brain, where they are targeted to specificExpand