• Publications
  • Influence
Steady-State Measurement of the Turnover of Amino Acid in the Cellular Proteins of Growing Escherichia coli: Existence of Two Kinetically Distinct Reactions
  • M. J. Pine
  • Medicine, Biology
  • Journal of bacteriology
  • 1 July 1970
TLDR
Intracellular proteolysis appears to be a normal and integral reaction of the growing cell and the total rate equals minimal estimates obtained by others for arrested or decelerated growth but is kinetically more heterogeneous. Expand
THE METHANE FERMENTATIONS OF ACETATE AND METHANOL
TLDR
The deuterium incorporation procedure previously employed for the study of the acetate fermentation was used to establish that all three hydrogen atoms attached to the carbon of methanol remained attached during methane formation and the relationship between meethanol and acetate utilization was investigated. Expand
Turnover of intracellular proteins.
  • M. J. Pine
  • Biology, Medicine
  • Annual review of microbiology
  • 1972
Taxonomic Comparison of the Amino Termini of Microbial Cell Proteins
TLDR
End-group analysis is particularly useful as a molecular criterion of taxonomy in assessing familial homogeneity and is consistent with its possible role as a general amino acid initiator of protein biosynthesis in the procaryotes. Expand
Regulation of Intracellular Proteolysis in Escherichia coli
  • M. J. Pine
  • Medicine, Biology
  • Journal of bacteriology
  • 1 July 1973
TLDR
Intracellular proteolysis is postulated to be regulated primarily by active ribosomal function and becomes maximally induced and unresponsive to normal regulatory control by metabolites at 43 to 45 C. Expand
Protein initiation without folate in Streptococcus faecium.
TLDR
A by-pass is suggested to alternate with conventional polypeptide initiation by substituting for covalent amine modification of methionyl-tRNA in mature S. faecium cell protein, which falls to half normal in folate depletion, accompanied by other changes in N-terminal profile. Expand
Comparative Physiological Effects of Incorporated Amino Acid Analogs In Escherichia coli
  • M. J. Pine
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1 April 1978
TLDR
Toxicity of the analog-substituted cell protein was most consistently indicated by its insolubility at graded temperatures, its increased breakdown, the relative suppression of further cell growth, and lethality, and the relative toxicity of poorly utilized analogs could be judged clearly only by the first two criteria. Expand
Response of Intracellular Proteolysis to Alteration of Bacterial Protein and the Implications in Metabolic Regulation
  • M. J. Pine
  • Medicine, Biology
  • Journal of bacteriology
  • 1 May 1967
TLDR
There is no correlation between metabolic stability of protein and the stability of its messenger ribonucleic acid. Expand
Heterogeneity of protein turnover in Escherichia coli.
  • M. J. Pine
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 8 July 1965
TLDR
The proteins synthesized in turnover are postulated to comprise a generally stable class derepressed by nutritional deficiency, and a more labile class which recycle non-specifically to contend with environmental alteration. Expand
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