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1 With isotonic recording the percentage of muscle shortening as compared with the maximal possible shortening, and with isometric recording the percentage of developed tension were determined. InExpand
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Some aspects of evolutionary pharmacology.
Abstract The main aim of evolutionary pharmacology is to understand the development of the chemical sensitivity of tissues and organs during the evolution of the animal kingdom. EvolutionaryExpand
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Pharmacology of the isolated heart of the lamprey Lampetra fluviatilis.
Abstract 1. 1. Acetylcholine (ACh) 10 −7 increases the rate of beating of the isolated lamprey heart; with higher concentrations a tonotropic effect and a contracture of ventricle muscle areExpand
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The role of carboxylic groups in the depolarizing action of some bisquaternary ammonium compounds and their derivatives on the neurons of the gastropod mollusc Limnaea stagnalis
Abstract 1. The depolarizing potency of the following three homological series: ‘BTM’: Me 3 N (CH 2 ) n NMe 3 , n = 9–16; ‘D’: Me 3 N CH 2 CH 2 O CO (CH 2 ) m CO O CH 2 CH 2 NMe 3 , m = 1–8;Expand
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The action of polymethylene-bistrimethylammonium compounds on the striated muscles of some representatives of different classes of vertebrates.
Abstract 1. 1. The polymethylene-bistrimethylammonium (BTM) series with 4–20 methylene groups between the nitrogens produce in the retractor linguae muscle of the cyclostome, Lampetra fluviatilis ,Expand
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Action of some bisquaternary derivatives of phthalic acids and related substances on neuromuscular transmission
1 All the bisquaternary derivatives of terephthalic acid with three methyl groups on each nitrogen atom (PK‐107, PK‐95, PK‐97 and PK‐126) were depolarizing neuromuscular blocking agents. The mostExpand
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The study of muscle cholinoreceptors using alkylating agents.
Abstract 1. 1. Structure-activity relationships were studied in a series of 2-halogenoethylamines which includes agents capable of alkylating both muscarinic and nicotinic cholinoreceptors. The mostExpand
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Acetylcholine: An Approach to the Molecular Mechanism of Action
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On the role of the ester groups in the internitrogen chain in the action of bisquaternary compounds on skeletal muscles.
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