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Hsp70 release from peripheral blood mononuclear cells.
RANK, RANKL and osteoprotegerin in bone biology and disease
- H. L. Wright, H. McCarthy, J. Middleton, M. J. Marshall
- BiologyCurrent reviews in musculoskeletal medicine
- 1 March 2009
This review aims to bring the interested reader up to date with the latest news and views on the mechanisms controlling bone resorption in normal and pathological conditions.
Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.
Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells.
Osteoblast: osteoclast co-cultures on silk fibroin, chitosan and PLLA films.
Platelet‐derived growth factor stimulates osteoprotegerin production in osteoblastic cells
- H. McCarthy, John H. H. Williams, M. Davie, M. J. Marshall
- Biology, MedicineJournal of cellular physiology
- 1 February 2009
The importance of PDGF in fracture healing suggests a role for OPG production in countering bone resorption during the early phase of this process, and it is demonstrated that PDGF acts through the PDGF receptor, PKC, PI3K, ERK and P38 and not via NF‐kB or JNK.
Dickkopf-1 as a potential therapeutic target in Paget's disease of bone
A new perspective on the aetiology of PDB is presented and evidence is adduced for the involvement of Wnt signalling, DKK-1 and osteoblasts in PDB pathogenesis.
Pamidronate stimulates recruitment and decreases longevity of osteoclast nuclei in mice.
An immunocytochemical method for studying the kinetics of osteoclast nuclei on intact mouse parietal bone
An immunocytochemical method using an antibody against 5-bromo-2′-deoxyuridine has been applied to the study of the kinetics of osteoclast nuclei on intact mouse parietal bones, with main advantages compared with autoradiography are the shortened processing time and the large number of osteoclasts that can be examined per parietal bone.