• Publications
  • Influence
Heterologous organisms (L. monocytogenes and S. typhimurium) were used to study the rate of development, magnitude, and persistence of the antimicrobial resistance engendered in mice by vaccinationExpand
  • 233
  • 6
  • PDF
Transfer of adoptive immunity to tuberculosis in mice.
A system is described for studying adoptive immunity to tuberculosis in syngeneic mice. Donor mice were immunized with 10(4) BCG intravenously, and lymphoid cells were harvested 28 days later.Expand
  • 91
  • 1
Host defenses in murine malaria: induction of a protracted state of immunity with a formalin-killed Plasmodium berghei blood parasite vaccine.
Random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of Plasmodium berghei, strain NYU-2, in combination with Corynebacterium parvum and/or living BCG. A highExpand
  • 6
  • 1
  • PDF
Use of serum antibody and lysozyme levels for diagnosis of leprosy and tuberculosis.
Active tuberculosis (TB) and leprosy are difficult to diagnose early because there are few organisms to detect and the specific immune response does not distinguish between active and inactiveExpand
  • 25
  • 1
  • PDF
Urinary phenolic glycolipid 1 in the diagnosis and management of leprosy.
A simplified assay to measure the phenolic glycolipid 1 (PGL-1) of Mycobacterium leprae in the urine was applied to the diagnosis of leprosy and the monitoring of antileprosy chemotherapy. OneExpand
  • 15
  • 1
Primary drug resistance in pulmonary tuberculosis in Great Britain: second national survey, 1963.
Summary A second national survey in Great Britain was conducted in 1963 to determine the prevalence of primary drug resistance to isoniazid, streptomycin and PAS and to compare the results with theExpand
  • 31
The measurement of tuberculin hypersensitivity in rats.
  • M. J. Lefford
  • Medicine
  • International archives of allergy and applied…
  • 1974
An objective and sensitive method is described for measuring tuberculin skin sensitivity in rats, based on the radioactive labelling with 3HT of bone marrow precursors of monocytes. These cellsExpand
  • 45
Relationship between delayed-type hypersensitivity and the progression of Mycobacterium lepraemurium infection.
The relationship between the level of delayed-type hypersensitivity (DTH) and the progression of Mycobacterium lepraemurium infection was examined after inoculation of mice with 10(8) M. lepraemuriumExpand
  • 16
Induction of cell-mediated immunity to Mycobacterium lepraemurium in susceptible mice.
A mouse strain (CB6) that is highly susceptible to Mycobacterium lepraemurium was infected with 10(8) bacilli into the hind footpad. These mice developed cell-mediated immunity to M. lepraemurium, asExpand
  • 24
  • PDF
Induction of cell-mediated immunity to Mycobacterium leprae in mice.
The immune response of mice to armadillo-derived, irradiation-killed Mycobacterium leprae (I-ML) was investigated. Following injection of 100 microgram of I-ML into the left hind footpads of mice, aExpand
  • 21