M. J. Humphrey

Publications74
h-index21
Citations1,674
Highly Influential Citations47
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Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans.
The pharmacokinetic profile of UK-49,858 (fluconazole), a novel triazole antifungal agent which is being developed for oral and intravenous use, was determined in mice, rats, dogs, and humans.… Expand
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The metabolism and pharmacokinetics of amlodipine in humans and animals.
The disposition of amlodipine, a new calcium-channel blocker with a slow onset and long duration of action, has been investigated in humans and in the animal species used in the evaluation of drug… Expand
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Metabolism and kinetics of amlodipine in man.
1. The disposition of amlodipine, R,S,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl- 5- methoxycarbonyl-6-methyl-1,4-dihydropyridine has been studied in two human volunteers using… Expand
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The systemic bioavailability of buprenorphine by various routes of administration
The systemic bioavailability of buprenorphine has been studied in female rats following single doses (200 μg kg−1) administered by one of six different routes. Relative to the 100% bioavailability… Expand
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Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces
Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration,… Expand
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Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril.
1. Candoxatrilat, an active neutral endopeptidase inhibitor, was released rapidly from the inactive prodrug candoxatril in vivo in mouse, rat, rabbit, dog and man. 2. Oral doses of [14C]-candoxatril… Expand
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The availability of carfecillin and its phenol moiety in rat and dog.
1. Studies have shown that hydrolysis of carfecillin to carbenicillin and phenol in vitro occurs in blood, liver and gut tissues of rat and dog. Extremely rapid hydrolysis was observed in the blood… Expand
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Biliary excretion, metabolism and enterohepatic circulation of buprenorphine.
1. After intramuscular administration of [3H]buprenorphine to rats, dogs, rhesus monkeys and one human volunteer, most of the dosed radioactivity was excreted in the faeces, indicating biliary… Expand
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Peptides and related drugs: a review of their absorption, metabolism, and excretion.
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Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.
Lyophilised wafers have potential as drug delivery systems for suppurating wounds. A dual series of wafers made from low molecular weight sodium alginate (SA) and xanthan gum (XG) respectively,… Expand
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