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Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans.
TLDR
Analysis of archival DNA samples from 71 Bornean and eight Sumatran orang-utans with a broad-spectrum PCR assay resulted in the detection of PyV infections in 11 animals from both species, and revealed a characteristic PyV architecture, but lacked an obvious agnogene.
Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk
TLDR
A combined risk allele score for single-nucleotide polymorphisms in four known FPG loci is significantly associated with FPG and HbA1c in a Dutch population-based sample of non-diabetic participants.
Rheb and Rags come together at the lysosome to activate mTORC1.
TLDR
Maturation of endosomes into lysosomes may be required to assure a continuous supply of GTP-bound Rheb for mTORC1 activation, which may help to drive the maturation process.
Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
TLDR
The results, based on hyperglycaemic clamps, provide further insight into the pathogenic mechanism behind the association of these gene variants with type 2 diabetes.
Rheb and mammalian target of rapamycin in mitochondrial homoeostasis
TLDR
The involvement of mTORC1 and Rheb in mitochondrial homoeostasis is reviewed and how mitochondrial function feeds back on m TORC1 via reactive oxygen species signalling to adapt metabolic processes is discussed.
Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
TLDR
Analysis of the TCR from different chimpanzee subspecies, and from a series of tissues from five individuals confirmed its genetic stability, and indicates that double-infections with different genotypes can occur.
Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps
TLDR
A combined risk allele score for eight known β-cell genes is associated with the rapid first-phase GSIS and the disposition index, suggesting that especially processes involved in rapid granule recruitment and exocytosis are affected in the majority of risk loci.
Molecular characterization of the first polyomavirus from a New World primate: squirrel monkey polyomavirus.
TLDR
The DNA samples from a variety of New World monkeys were screened by using a broad-spectrum PCR targeting the VP1 gene of polyomaviruses, and phylogenetic analysis of theVP1 gene confirmed its uniqueness.
Mammalian Target of Rapamycin Complex I (mTORC1) Activity in Ras Homologue Enriched in Brain (Rheb)-Deficient Mouse Embryonic Fibroblasts
TLDR
Whereas rapid adaptation in mTORC1 activity requires Rheb, a second RheB-independent activation mechanism exists that contributes to cell cycle progression, and it is shown that this rapamycin-sensitive, R heb-independent mTORc1 activity is important for cell cycle progressions.
Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study
TLDR
This study aimed to identify association of common polymorphisms in nuclear-encoded genes involved in mitochondrial protein synthesis and biogenesis with type II diabetes mellitus (T2DM) using a two-stage design and did not find evidence of common variants in 13 nuclear- Encoded mitochondrial proteins with T2DM.
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