The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance.
- A. J. Castro, M. J. Frederico, F. R. Silva
- Medicine, BiologyBiochimica et Biophysica Acta
- 2015
The role of calcium in intracellular pathways of rutin in rat pancreatic islets: potential insulin secretagogue effect.
- V. Kappel, M. J. Frederico, Barbara G Postal, C. P. Mendes, L. H. Cazarolli, F. R. Silva
- Biology, MedicineEuropean Journal of Pharmacology
- 28 February 2013
N-(1'-naphthyl)-3,4,5-trimethoxybenzohydrazide as microtubule destabilizer: Synthesis, cytotoxicity, inhibition of cell migration and in vivo activity against acute lymphoblastic leukemia.
- L. B. Salum, A. Mascarello, R. Nunes
- Chemistry, BiologyEuropean journal of medicinal chemistry
- 26 May 2015
Betulinic acid and 1,25(OH)₂ vitamin D₃ share intracellular signal transduction in glucose homeostasis in soleus muscle.
- A. J. Castro, M. J. Frederico, F. R. Silva
- Biology, MedicineInternational Journal of Biochemistry and Cell…
- 1 March 2014
Oral Mucosa Model for Electrochemotherapy Treatment of Dog Mouth Cancer: Ex Vivo, In Silico, and In Vivo Experiments
- D. Suzuki, J. Berkenbrock, M. J. Frederico, Fátima R M B Silva, M. Rangel
- MedicineArtificial Organs
- 1 March 2018
The numerical modeling for treatment planning will help the development of new electrodes and increase the EQT effectiveness, and this electroporation model was used with a spontaneous canine oral melanoma.
Acylhydrazones contribute to serum glucose homeostasis through dual physiological targets.
- M. J. Frederico, A. J. Castro, F. R. Silva
- Biology, MedicineCurrent Topics in Medicinal Chemistry
- 30 September 2012
The results of this study indicate dual physiological targets for the acylhydrazone 1, i.e., pancreatic islets and skeletal muscle, as a result of insulin secretagogue and insulinomimetic action.
Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: Evidence for the mechanisms of action.
- Catharina Nucci-Martins, D. Martins, A. Santos
- BiologyJournal of Ethnopharmacology
- 4 December 2015
Brain bioenergetics in rats with acute hyperphenylalaninemia
- N. W. Dimer, B. K. Ferreira, P. F. Schuck
- Biology, ChemistryNeurochemistry International
- 1 July 2018
Mechanism of Action of Novel Glibenclamide Derivatives on Potassium and Calcium Channels for Insulin Secretion.
- M. J. Frederico, A. J. Castro, F. R. Silva
- Biology, MedicineCurrent Drug Targets
- 1 May 2017
The aim of this review was to highlight the main mechanism of action of glibenclamide and the influence of its derivatives, such as acylhydrazones, sulfonamides and sulfonylthioureas on β-cells potassium and calcium channels for insulin secretion as well as the contribution of these new compounds to restore glucose homeostasis.
Bis‐Pyrano Prenyl Isoflavone Improves Glucose Homeostasis by Inhibiting Dipeptidyl Peptidase‐4 in Hyperglycemic Rats
- D. Altenhofen, Gabrielle da Luz, F. R. M. B. Silva
- BiologyJournal of Cellular Biochemistry
- 1 January 2017
The in vivo and in vitro action of the isoflavone exhibits an anti‐hyperglycemic effect by improving glucose tolerance, augmenting the liver glycogen, inhibiting maltase activity, and stimulating glucagon‐like peptide‐1 (GLP‐1) and insulin secretion and the long‐term effect of is oflavone prevents protein glycation.
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