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Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver‐ and muscle‐specific glycogen binding subunits of protein phosphatase 1
TLDR
The amino acid sequence and properties of PPP1R5 indicate that it is not subject to the same modes of covalent and allosteric regulation by hormones as are Gm and GL, and differs from GL in being present in a wide variety of tissues, besides liver. Expand
Amino acid sequence and expression of the hepatic glycogen‐binding (GL‐subunit of protein phosphatase‐1
TLDR
A full‐length cDNA encoding the putative hepatic glycogen‐binding subunit of protein phosphatase‐1 (PP1) was isolated from a rat liver library, and experiments establish that the cloned protein is GL. Expand
Identification of the separate domains in the hepatic glycogen-targeting subunit of protein phosphatase 1 that interact with phosphorylase a, glycogen and protein phosphatase 1.
Deletion and mutational analyses of the rat liver glycogen-targeting subunit (GL) of protein phosphatase 1 (PP1) have identified three separate domains that are responsible for binding of PP1,Expand
Monoclonal Antibodies in Simultaneous Marking Elisa Systems
Abstract Binding immunoassays (such as the ELISA) based upon paired antibodies directed against spatially distinct epitopes on the same antigen molecule, have the advantage that all of the reagentsExpand
Loss of the hepatic glycogen-binding subunit (GL) of protein phosphatase 1 underlies deficient glycogen synthesis in insulin-dependent diabetic rats and in adrenalectomized starved rats.
TLDR
The regulation of GL protein levels by insulin and starvation/feeding was shown to correlate with changes in the level of the GL mRNA, indicating that the long-term regulation of the hepatic glycogen-associated form of PP1 by insulin, and hence the activity of hepatic Glycogen synthase phosphatase, is predominantly mediated through changes inThe level ofthe GL mRNA. Expand
Antigen Triggering Selectively Increases TCRBV Gene Transcription1
TLDR
It is conclusively demonstrated that there is no direct relationship between TCRBV mRNA and T cell number, and that future repertoire studies must take both factors into account. Expand
Protein domains in the regulatory subunit of liver glycogen protein phosphatase 1 and their methods of production and utilization.
Un compuesto que es capaz de bloquear la interaccion de fosforilasa alfa con la subunidad reguladora de glucogeno (GL) de la proteina fosfatasa para uso en medicina, donde el compuesto es (1) unExpand
TCRBV Gene Transcription Antigen Triggering Selectively Increases
Martin J. Doherty and Richard A. KayGreig P. Lennon, James E. Sillibourne, Elizabeth Furrie,http://www.jimmunol.org/content/165/4/2020J Immunol€2000; 165:2020-2027;Expand