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The Transcriptional Landscape of the Mammalian Genome
Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
Signaling mechanisms underlying the vascular myogenic response.
The purpose of this review is to summarize and synthesize information regarding the cellular mechanism(s) underlying the myogenic response in blood vessels, with particular emphasis on arterioles.
Acid tolerance in Listeria monocytogenes: the adaptive acid tolerance response (ATR) and growth-phase-dependent acid resistance.
Listeria monocytogenes acquired increased acid tolerance during exponential growth upon exposure to sublethal acid stress, a response designated the acid tolerance response (ATR), and developed increased acid resistance upon entry into the stationary phase; this response appeared to be independent of the pH-dependent ATR seen during exponential Growth.
Endothelium-dependent, flow-induced dilation of isolated coronary arterioles.
Flow-mediated dilation has been documented in large conduit coronary arteries but not in coronary arterioles and whether it competes with myogenic constriction is investigated, and spontaneous tone and myogenic responses were preserved, but flow- induced dilation and bradykinin-induced dilation were abolished.
Myogenic response gradient in an arteriolar network.
  • M. J. Davis
  • Biology, Medicine
    The American journal of physiology
  • 1 June 1993
A compilation of data from numerous in vivo and in vitro studies suggests that the same myogenic response pattern may be found in other vascular beds.
Invited review: arteriolar smooth muscle mechanotransduction: Ca(2+) signaling pathways underlying myogenic reactivity.
The smooth muscle of arterioles responds to an increase in intraluminal pressure with vasoconstriction and with vasodilation when pressure is decreased, and the purpose of this brief review is to summarize the current literature relating to Ca(2+) and the arteriolar myogenic response.
Longitudinal gradients for endothelium-dependent and -independent vascular responses in the coronary microcirculation.
Testing the hypothesis that a longitudinal gradient for shear stress- and agonist-induced dilation exists in the coronary microcirculation indicates that the pig coronary circulation exhibits a heterogeneity in physiological and pharmacological responses along the microvascular network.
Regulation of ion channels by protein tyrosine phosphorylation.
This review presents a comprehensive summary and synthesis of the literature regarding the mechanism and function of ion channel regulation by protein tyrosine kinases and phosphatases, and discusses the critical roles that channel-associated scaffolding proteins may play in localizing protein tyrolysis and phosphorylation to the vicinity of ion channels.