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Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) is a key enzyme that plays an important role in SARS virus replication. The ethanol extract of the seedsExpand
Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa
Abstract SARS-CoV papain-like protease (PLpro) is an important antiviral target due to its key roles in SARS virus replication. The MeOH extracts of the fruits of the Paulownia tree yielded manyExpand
Polyphenols from Broussonetia papyrifera displaying potent alpha-glucosidase inhibition.
  • H. Ryu, B. Lee, +4 authors K. Park
  • Chemistry, Medicine
  • Journal of agricultural and food chemistry
  • 13 January 2010
The organic extract of the roots of Broussonetia papyrifera showed extremely high alpha-glucosidase inhibitory activity with an IC50 of around 10 microg/mL. Due to its potency, subsequentExpand
Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki.
Six 1,3-diphenylpropanes exhibiting inhibitory activities against both the monophenolase and diphenolase actions of tyrosinase were isolated from the methanol (95%) extract of Broussonetia kazinoki.Expand
The most abundant polyphenol of soy leaves, coumestrol, displays potent α-glucosidase inhibitory activity
Abstract The leaves of soybean ( Glycine max ) were extracted into four different polar solvents: ethylacetate, butanol, ethanol and water. The ethylacetate extract (EE) showed the lowest IC 50 valueExpand
Sulfonamide chalcone as a new class of α-glucosidase inhibitors
Abstract Chalcones 1 – 20 , a new class of glycosidase inhibitors, were synthesized, and their glycosidase inhibitory activities were investigated. Non-aminochalcones 1 – 12 had no inhibitoryExpand
Isolation of cholinesterase-inhibiting flavonoids from Morus lhou.
Cholinesterases are key enzymes that play important roles in cholinergic transmission. Nine flavonoids displaying cholinesterase inhibitory activity were isolated from the root bark of Morus lhou L.,Expand
Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits.
Tribulus terrestris fruits are well known for their usage in pharmaceutical preparations and food supplements. The methanol extract of T. terrestris fruits showed potent inhibition against theExpand
Tyrosinase inhibitory polyphenols from roots of Morus lhou.
Twelve polyphenols (1-12) possessing tyrosinase inhibitory properties were isolated from the methanol (95%) extract of Morus lhou. The isolated compounds consisted of four flavanones (1-4), fourExpand
Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone.
  • W. Seo, Y. Ryu, +4 authors K. Park
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 1 May 2010
The 4'-(p-toluenesulfonylamino)-4-hydroxychalcone (TSAHC), which bears inhibitory chemotypes for both alpha-glucosidase and tyrosinase, was evaluated for tyrosinase activity and depigmenting abilityExpand