M. J. Crawford

Publications32
h-index10
Citations2,056
Highly Influential Citations107
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Tropical infectious diseases: Metabolic maps and functions of the Plasmodium falciparum apicoplast
Discovery of a relict chloroplast (the apicoplast) in malarial parasites presented new opportunities for drug development. The apicoplast – although no longer photosynthetic – is essential to… Expand
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Draft Genome of the Filarial Nematode Parasite Brugia malayi
Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the ∼90 megabase (Mb) genome of the human filarial… Expand
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The Plastid of Toxoplasma gondii Is Divided by Association with the Centrosomes
Apicomplexan parasites harbor a single nonphotosynthetic plastid, the apicoplast, which is essential for parasite survival. Exploiting Toxoplasma gondii as an accessible system for cell biological… Expand
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Toxoplasma gondii scavenges host‐derived lipoic acid despite its de novo synthesis in the apicoplast
In contrast to other eukaryotes, which manufacture lipoic acid, an essential cofactor for several vital dehydrogenase complexes, within the mitochondrion, we show that the plastid (apicoplast) of the… Expand
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The glycosynapse
MICROBIOLOGY. For the article ‘‘Subcellular localization of acetylCoA carboxylase in the apicomplexan parasite Toxoplasma gondii,’’ by J. Jelenska, M. J. Crawford, O. S. Harb, E. Zuther, R.… Expand
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Multiple Functionally Redundant Signals Mediate Targeting to the Apicoplast in the Apicomplexan Parasite Toxoplasma gondii
ABSTRACT Most species of the protozoan phylum Apicomplexa harbor an endosymbiotic organelle—the apicoplast—acquired when an ancestral parasite engulfed a eukaryotic plastid-containing alga. Several… Expand
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Origin, targeting, and function of the apicomplexan plastid.
The discovery of a plastid in Plasmodium, Toxoplasma and related protozoan parasites provides a satisfying resolution to several long-standing mysteries: the mechanism of action for various… Expand
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Transport and trafficking: Toxoplasma as a model for Plasmodium.
Like Plasmodium, the protozoan parasite Toxoplasma gondii is a member of the phylum Apicomplexa, and an obligate intracellular pathogen. Unlike Plasmodium, however, Toxoplasma is highly amenable to… Expand
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Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii
Apicomplexan parasites such as Toxoplasma gondii contain a primitive plastid, the apicoplast, whose genome consists of a 35-kb circular DNA related to the plastid DNA of plants. Plants synthesize… Expand
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Mining the Plasmodium genome database to define organellar function: what does the apicoplast do?
Apicomplexan species constitute a diverse group of parasitic protozoa, which are responsible for a wide range of diseases in many organisms. Despite differences in the diseases they cause, these… Expand
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