• Publications
  • Influence
Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.
The pharmacology of several commonly described 5-hydroxytryptamine (5-HT)(2C) receptor agonists was investigated in vivo and in vitro at rat 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors. The 5-HT(2C)Expand
  • 63
  • 7
5-HT2C receptor agonists as potential drugs for the treatment of obesity.
  • M. J. Bickerdike
  • Biology, Medicine
  • Current topics in medicinal chemistry
  • 1 May 2003
An association between the brain serotonin (5-HT) system and feeding has been postulated since the 1970's but it has only been in recent years that the nature of 5-HT-mediated hypophagia has becomeExpand
  • 75
  • 2
NNZ-2566: A Gly–Pro–Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke
The N-terminal cleavage product of human insulin-like growth factor-1 (IGF-1) in the brain is the tripeptide molecule Glypromate (Gly-Pro-Glu). Glypromate has demonstrated neuroprotective effects inExpand
  • 23
  • 2
Comparative effects of continuous infusion of mCPP, Ro 60‐0175 and d‐fenfluramine on food intake, water intake, body weight and locomotor activity in rats
The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5‐HT2C receptor agonists, m‐chlorophenylpiperazine (mCPP, 12 mg kg−1 day−1) and Ro 60‐0175 (36 mg kg−1 day−1)Expand
  • 75
  • 1
Oral administration of the 5-HT2C receptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia
RationaleThe 5-HT2C receptor subtype has been implicated extensively in the regulation of ingestive behaviour.ObjectiveTo assess whether chronic administration of the preferential 5-HT2C receptorExpand
  • 76
  • 1
5‐HT2C receptor modulation and the treatment of obesity
  • 44
Indoline derivatives as 5-HT(2C) receptor agonists.
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles areExpand
  • 34
  • PDF
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.
Further lead optimization efforts on previously described 1,2,3,4,10,10a-hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of 5,5a,6,7,8,9-hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazinesExpand
  • 22
Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.
Synthesis and evaluation of the activity of new 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT(2C) receptor agonists are described. Appropriately substituted, several analogsExpand
  • 21
Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursorExpand
  • 16
...
1
2
...