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Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.
TLDR
Sildenafil is shown to enhance the erectile response (duration and rigidity of erection) to visual sexual stimulation, thus highlighting the important role of PDE5 in human penile erection. Expand
Pharmacokinetics and Safety of Voriconazole following Intravenous- to Oral-Dose Escalation Regimens
TLDR
The safety, tolerability, and pharmacokinetics of intravenous- to oral-dose regimens of voriconazole were evaluated with a group of 42 healthy men; the most commonly reported adverse events in vorIconazole-treated subjects were mild to moderate headache, rash, and abnormal vision. Expand
Effects of sildenafil citrate on human hemodynamics.
TLDR
Sildenafil was well tolerated by subjects and patients in all studies, with headache and other symptoms of vasodilation the most commonly reported adverse effects of treatment. Expand
Dofetilide, A Novel Class III Antiarrhythmic Agent
TLDR
Pharmacodynamic data demonstrate dose- and concentration-dependent effects on myocardial repolarization as evidenced by prolongations of the QTC interval, supporting the contention that dofetilide is a highly selective class III antiarrhythmic agent. Expand
Sildenafil, a novel effective oral therapy for male erectile dysfunction.
TLDR
Results show that sildenafil is a well tolerated and effective oral therapy for male erectile dysfunction with no established organic cause and may represent a new class of peripherally acting drug for the treatment of this condition. Expand
Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist.
TLDR
Sildenafil potentiated the hypotensive effects of glyceryl trinitrate, an organic nitrate, which is a well-tolerated and highly effective treatment for erectile dysfunction but whose administration to patients who are using organic nitrates, either regularly and/or intermittently, in any form is contraindicated. Expand
Voriconazole, a novel wide-spectrum triazole: oral pharmacokinetics and safety.
TLDR
Plasma concentrations of voriconazole were well above the minimum inhibitory concentrations for Aspergillus spp. Expand
Vascular responses to local atrial natriuretic peptide infusion in man.
TLDR
The findings indicate that ANP acting locally, is an arterioselective dilator in the upper limb circulation in normal man, and circulating levels of ANP may be within a range capable of influencing peripheral vascular resistance directly. Expand
Pharmacokinetics, Pharmacodynamics, and Safety of the 5‐HT1B/1D Agonist Eletriptan following Intravenous and Oral Administration
TLDR
E letriptan was well tolerated, and treatment‐related adverse events were mild to moderate and transient, and PK properties should result in eletriptan having a rapid onset and sustained duration of action in terms of migraine efficacy. Expand
Pharmacokinetics, pharmacodynamics, and safety of the 5-HT(1B/1D) agonist eletriptan following intravenous and oral administration.
TLDR
E letriptan was well tolerated, and treatment-related adverse events were mild to moderate and transient, and PK properties should result in eletriptan having a rapid onset and sustained duration of action in terms of migraine efficacy. Expand
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