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A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium
TLDR
In vivo infection study using mice clearly indicated that the administration of aurodox allowed the mice to survive a lethal dose of Citrobactor rodentium, a model bacterium for human pathogens such as EPEC, and directly demonstrated for the first time that this putative T3SS inhibitor can be applied as a novel class of anti-infective agents.
Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum
Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum
Lariatins, Novel Anti-mycobacterial Peptides with a Lasso Structure, Produced by Rhodococcus jostii K01-B0171
Two anti-mycobacterial peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of Rhodococcus
Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure.
Two antimycobacterial agents, lariatins A and B, were isolated from the culture broth of Rhodococcus sp. K01-B0171. Their structures were elucidated by spectral analysis and advanced protein chemical
Penicillium viticola, a new species isolated from a grape in Japan
TLDR
A new monoverticillate Penicillium species (subgenus Aspergilloides Dierckx) was isolated from a grape cultivated in Yamanashi Prefecture, Japan and is characterized by the production of slightly roughened conidia, slightly rouGhened stipes, and rapid growth on 25% glycerol nitrate agar (G25N).
Spoxazomicins A–C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T
TLDR
Three novel antitrypanosomal alkaloids were isolated by silica gel column chromatography and HPLC from the culture broth of a new endophytic actinomycete species and shown to be new types of pyochelin family antibiotic.
Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites.
TLDR
It is reported that a novel borrelidin analogue, bearing the CH2SPh moiety via a triazole linkage, was found to retain a potent antimalarial activity, against drug-sensitive and drug-resistant parasite strains, but possess only weak cytotoxicity against human cells.
In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.
TLDR
This finding represents the first report of promising trypanocidal activity of these terpenes and provides some valuable insight with regard to structure-activity relationships and the possible mode of action of the compounds.
Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509
TLDR
Using this assay, six structurally related compounds designated as guadinomines were isolated as inhibitors of TTSS-induced hemolysis by ion exchange column chromatography and HPLC from the culture broth of Streptomyces sp.
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