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A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium
The type III secretion system (T3SS) is highly conserved in many Gram-negative pathogenic bacteria and functions as an injector of bacterial proteins (effectors) into host cells. T3SSs are involvedExpand
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Lariatins, Novel Anti-mycobacterial Peptides with a Lasso Structure, Produced by Rhodococcus jostii K01-B0171
Two anti-mycobacterial peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of RhodococcusExpand
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Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum
Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum
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Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure.
Two antimycobacterial agents, lariatins A and B, were isolated from the culture broth of Rhodococcus sp. K01-B0171. Their structures were elucidated by spectral analysis and advanced protein chemicalExpand
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Penicillium viticola, a new species isolated from a grape in Japan
A new monoverticillate Penicillium species (subgenus Aspergilloides Dierckx), Penicillium viticola, was isolated from a grape cultivated in Yamanashi Prefecture, Japan. Morphologically, P. viticolaExpand
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Action of beta-carotene as an antioxidant against lipid peroxidation.
The action and activity of beta-carotene as a radical-scavenging antioxidant against lipid peroxidation have been studied. beta-Carotene suppressed the free-radical-mediated oxidations of methylExpand
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Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509
Enteropathogenic Escherichia coli (EPEC) expressing the Type III secretion system (TTSS) induced hemolysis of sheep blood cells. Using this assay, six structurally related compounds designated asExpand
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In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.
During the course of screening to discover antitrypanosomal compounds, 24 known plant terpenes (6 sesquiterpenes, 14 sesquiterpene lactones and 4 diterpenes) were evaluated for in vitroExpand
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Spoxazomicins A–C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T
Three novel antitrypanosomal alkaloids, named spoxazomicins A–C, were isolated by silica gel column chromatography and HPLC from the culture broth of a new endophytic actinomycete species,Expand
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