• Publications
  • Influence
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)*
The small GTPase Rho is implicated in physiological functions associated with actin-myosin filaments such as cytokinesis, cell motility, and smooth muscle contraction. We have recently identified andExpand
  • 1,924
  • 193
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells.Expand
  • 2,824
  • 142
Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase*
It is clear from several studies that myosin phosphatase (MP) can be inhibited via a pathway that involves RhoA. However, the mechanism of inhibition is not established. These studies were carriedExpand
  • 520
  • 64
Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.
The small GTP binding protein Rho is implicated in cytoskeletal responses to extracellular signals such as lysophosphatidic acid to form stress fibers and focal contacts. Here we have purified aExpand
  • 1,030
  • 55
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.
Familial adenomatous polyposis coli (FAP) is a disease characterized by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene. With theExpand
  • 522
  • 31
Phosphorylation of CPI‐17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho‐kinase
Phosphorylation of CPI‐17 by Rho‐associated kinase (Rho‐kinase) and its effect on myosin phosphatase (MP) activity were investigated. CPI‐17 was phosphorylated by Rho‐kinase to 0.92 mol of P/mol ofExpand
  • 232
  • 23
Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation*
Small GTPase Rho plays pivotal roles in the Ca2+ sensitization of smooth muscle. However, the GTP-bound active form of Rho failed to exert Ca2+-sensitizing effects in extensively TritonExpand
  • 585
  • 21
Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.
Contraction and relaxation of smooth muscle are regulated by myosin light-chain kinase and myosin phosphatase through phosphorylation and dephosphorylation of myosin light chains. Cyclic guanosineExpand
  • 487
  • 20
Rho-associated Kinase of Chicken Gizzard Smooth Muscle*
Rho-associated kinase (Rho-kinase) from chicken gizzard smooth muscle was purified to apparent homogeneity (160 kDa on SDS-polyacrylamide gel electrophoresis) and identified as the ROKα isoform.Expand
  • 261
  • 16
GIGAS CELL1, a Novel Negative Regulator of the Anaphase-Promoting Complex/Cyclosome, Is Required for Proper Mitotic Progression and Cell Fate Determination in Arabidopsis[W]
A novel plant-specific inhibitor of anaphase-promoting complex/cyclosome was identified from the gigas cell1 (gig1) mutation, which causes polyploidization of somatic cells due to ectopicExpand
  • 83
  • 13
  • PDF