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Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes.
Obesity, characterized by an excess of adipose tissue, is an established risk factor for cardiovascular disease and type 2 diabetes. Different mechanisms linking obesity with these comorbidities have… Expand
Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells
In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known… Expand
Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma
- M. Issa, Farnaz Sedigheh Takhsha, C. S. Chirumamilla, C. Pérez-Novo, W. Vanden Berghe, M. Cuendet
- Biology, Medicine
- Clinical Epigenetics
- 10 February 2017
Multiple myeloma (MM) is a hematological malignancy, which remains incurable because most patients eventually relapse or become refractory to current treatments. Due to heterogeneity within the… Expand
Withaferin A induces cell death and differentiation in multiple myeloma cancer stem cells.
Multiple myeloma (MM) remains an incurable malignancy despite the development of novel therapeutics. This is believed to be due to a subset of rare chemotherapy-resistant cancer stem cells (CSCs).… Expand
Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6
Little is known about the biological and structural features that govern the isoform selectivity for class I histone deacetylases (HDACs) over HDAC6. In addition to that for known inhibitors, like… Expand
Targeting Multiple Myeloma Cancer Stem Cells with Natural Products - Lessons from Other Hematological Malignancies.
Multiple myeloma is characterized by the accumulation of malignant plasma cells in the bone marrow. Multiple myeloma is the second most frequently diagnosed hematological malignancy, predominantly… Expand
Bruceantin inhibits multiple myeloma cancer stem cell proliferation
- M. Issa, S. Berndt, G. Carpentier, J. Pezzuto, M. Cuendet
- Biology, Medicine
- Cancer biology & therapy
- 19 July 2016
ABSTRACT Multiple myeloma (MM) continues to claim the lives of a majority of patients. MM cancer stem cells (CSCs) have been demonstrated to sustain tumor growth. Due to their ability to self-renew… Expand
A Bivalent Role of Genistein in Sprouting Angiogenesis.
The effects of genistein on angiogenesis remain poorly understood. Some studies claim an antiangiogenic effect and others claim a pro-angiogenic one. Thus, the aim of this study was to determine if… Expand
Characterization of the Expression and Function of Chemerin and CMKLR1 within the Central Nervous System
Quand implanter un stimulateur cardiaque après remplacement valvulaire aortique percutané ? Revue de littérature
Resume Le transcatheter aortic valve implantation (TAVI) est actuellement une technique tres repandue dans le traitement des stenoses aortiques. L’une des principales complications liee a cette… Expand