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l-arginine improves dystrophic phenotype in mdx mice
TLDR
The results suggest that pharmacological activators of the NO pathway may constitute a realistic treatment for Duchenne and Becker muscular dystrophies. Expand
Increase in External Glutamate and NMDA Receptor Activation Contribute to H2O2‐Induced Neuronal Apoptosis
TLDR
The major part of H2O2‐induced neurotoxicity is mediated by the formation of hydroxyl radicals, which might be involved in (a) the delayed accumulation of extracellular glutamate and NMDA receptor activation and (b) the poly(ADP‐ribose) polymerase activation and the related NAD content decrease. Expand
Pyruvate and lactate protect striatal neurons against N‐methyl‐d‐aspartate‐induced neurotoxicity
TLDR
Pyruvate and l‐lactate strongly counteracted the deep decrease in the neuronal ATP content induced by NMDA, indicating that they might protect striatal neurons by rescuing cellular energy charge. Expand
Routes of zinc entry in mouse cortical neurons: role in zinc-induced neurotoxicity.
TLDR
The results suggest that Zn2+ detected with TSQ in neurons is mainly bound to membranes, which might be responsible for the delayed NMDA receptor activation that leads to neuronal death. Expand
Coregulation of Two Embedded Gene Products, Choline Acetyltransferase and the Vesicular Acetylcholine Transporter
TLDR
The effects on VAChT gene expression of the cholinergic differentiation factor/leukemia inhibitory factor and retinoic acid, both of which induce ChAT activity and increase ChAT mRNA levels in cultured sympathetic neurons, are tested and suggest a functional role for ChAT and VA choline acetylcholine transporter. Expand
Nitric Oxide and l -Arginine Cause an Accumulation of Utrophin at the Sarcolemma: A Possible Compensation for Dystrophin Loss in Duchenne Muscular Dystrophy
TLDR
It is shown that in adult normal and mdx mice (an animal model of Duchenne myopathy) treated with l-arginine, the substrate of nitric oxide synthase (NOS), a pool of utrophin localized at the membrane appeared and increased and increased, respectively. Expand
Continuous Determination by a Chemiluminescent Method of Acetylcholine Release and Compartmentation in Torpedo Electric Organ Synaptosomes
TLDR
It is shown that synaptosomes contain only negligible amounts of choline, and that the proportion of the two ACh compartments is not influenced by changing extracellular calcium just before their determination. Expand
The metabolic advantage of tumor cells
TLDR
Oncogenes express proteins of "Tyrosine kinase receptor pathways", a receptor family including insulin or IGF-Growth Hormone receptors, which alter the PP2A phosphatase brake over these kinases, which results in choline protection and inhibition of kinases activated by the boosted signaling pathway. Expand
The isolation of mossy fibre endings from the granular layer of the cerebellar cortex
TLDR
La fusion intracytoplasmique des vésicules synaptiques se produisant sous l'effet de the chaleur indiquerait un mécanisme de libération du médiateur. Expand
Application to Mammalian Tissues of the Chemiluminescent Method for Detecting Acetylcholine
TLDR
It is now possible to extend to mammalian tissues the chemilumi‐nescent acetylcholine assay and it is shown that release experiments can be performed on mammalian tissue slices after the slice is washed in oxygenated saline solutions. Expand
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