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Antioxidant, antinociceptive activity and general toxicity study of Dendrophthoe falcata and isolation of quercitrin as the major component
Plants have been used in traditional medicinal system for centuries. Bangladeshi medicinal plants have received considerable attention from the researchers for evaluation of their bioactivity. As a
Analgesic components of saposhnikovia root (Saposhnikovia divaricata).
By activity-oriented separation using the writhing method in mice, the analgesic components of Saposhnikovia root were identified to be chromones, coumarins, polyacetylenes and 1-acylglycerols, and two new components, divaricatol and (3'S)-hydroxydeltoin were also isolated.
Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities.
According to the traditional usage of the plant for antiinflammation and analgesia, Leucas aspera was tested for its prostaglandin (PG) inhibitory and antioxidant activities and LA-8 was determined to be (-)-chicanine, the new antipode of the (+) compound by spectroscopic methods including CD and ORD.
Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum.
A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three
Lignan glycosides and flavonoids from Saraca asoca with antioxidant activity
Five lignan glycosides, lyoniside, nudiposide, 5-methoxy-9-β-xylopyranosyl-(−)-isolariciresinol, icariside E3, and schizandriside, and three flavonoids, (−)-epicatechin,
Terpenoids and a flavonoid glycoside from Acacia pennata leaves as hedgehog/GLI-mediated transcriptional inhibitors.
Three compounds identified as Hh/GLI inhibitors exhibited selective cytotoxicity against human pancreatic and prostate cancer cells with no toxic effect on normal cells, consistent with a dose-dependent reduction of the protein levels of antiapoptotic BCL-2 and the tumor suppressor patched 1 protein.
Naturally Occurring Small‐Molecule Inhibitors of Hedgehog/GLI‐Mediated Transcription
The results strongly suggest that the cytotoxicity of the compounds to PANC1 cells correlates with their inhibition of GLI‐mediated transcription, and that these compounds were cytotoxic to P ANC1 pancreatic cancer cells, which express Hh/GLI components.
Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL‐induced apoptosis
Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2–3). Compound 1 showed strong activity in