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Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a
It is suggested that EGCG executed apoptotic cell death via an ASK1, MKK and JNK/p38 cascade which is triggered by NAC-sensitive intracellular oxidative events in a manner distinct from chemically induced or receptor-mediated apoptosis. Expand
The fucosylation index of alpha‐fetoprotein and its usefulness in the early diagnosis of hepatocellular carcinoma
Data indicate that the measurement of the fucosylation index of AFP is useful for the early diagnosis of HCC, and these values were higher, with statistical significance, than those in patients with benign liver diseases. Expand
Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells.
ECg was considered to be the agent with the most potential antimetastasis activity because it inhibited invasion in the absence of cytotoxicity against cancer cells and HUVECs. Expand
Apoptosis induction by epigallocatechin gallate involves its binding to Fas.
The results suggest that EGCG-binding to Fas, presumably on the cell surface, triggers the Fas-mediated apoptosis in U937 cells. Expand
Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080
Matrix metalloproteinases (MMPs) play a crucial role in the process of cancer invasion and metastasis. Previous findings suggested that epigallocatechin gallate (EGCG), a main flavanol of green tea,Expand
Apoptosis Induction by Lectin Isolated from the Mushroom Boletopsis leucomelas in U937 Cells
The Kurokawa lectin is the first mushroom lectin with apoptosis-inducing activity and was observed to induced apoptotic bodies formation, chromatin condensation, and DNA ladder formation, features of apoptosis. Expand
Inhibitory effect of epigallocatechin gallate on adhesion of murine melanoma cells to laminin.
The inhibitory effect of EGCG on adhesion of melanoma cells to laminin is included in the mechanism(s) of previously reported metastasis inhibition elicited by E GCG and green tea infusion. Expand
Fucosylation Index of α‐Fetoprotein, a Possible Aid in the Early Recognition of Hepatocellular Carcinoma in Patients with Cirrhosis
It is indicated that the fucosylation index of α‐fetoprotein can be used as an aid in an early recognition of hepatocellular carcinoma, especially in patients with cirrhosis during the follow‐up process in which the moderate increment of serum concentration of α-fetop Protein is noted. Expand
Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites
The in vitro experiments suggested that EGCG and its metabolites could reach the brain parenchyma through the blood–brain barrier and induce neuritogenesis suggest that metabolites of E GCG may play an important role in reducing neurodegenerative diseases. Expand
Importins and exportins in cellular differentiation
In cellular differentiation, HL‐60 cell differentiation, terminal erythroìd differentiation, neural differentiation, cardiac differentiation, and Keratìnocyte differentiation. Expand