• Publications
  • Influence
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.
TLDR
The zoster vaccine markedly reduced morbidity from herpes zoster and postherpetic neuralgia among older adults and significantly reduced the burden of illness due to herpesZoster.
From stress to inflammation and major depressive disorder: a social signal transduction theory of depression.
TLDR
A biologically plausible, multilevel theory is proposed that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental stress with internal biological processes that drive depression pathogenesis and may shed light on several important questions including how depression develops, why it frequently recurs, and why it is strongly predicted by early life stress.
Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?
TLDR
This study confirms high rates of behavioral symptoms in breast cancer survivors, particularly those treated with chemotherapy, and indicates a role for TNF-α signaling as a contributor to postchemotherapy fatigue.
Validation of a 3-factor scoring model for the Pittsburgh sleep quality index in older adults.
TLDR
These findings validate the factor structure of the PSQI and demonstrate that a 3-factor score should be used to assess disturbances in three separate factors of subjective sleep reports.
Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation.
TLDR
Sleep loss induces a functional alteration of the monocyte proinflammatory cytokine response, which alters molecular processes that drive cellular immune activation and induce inflammatory cytokines; mapping the dynamics of sleep loss on molecular signaling pathways has implications for understanding the role of sleep in altering immune cell physiologic characteristics.
Reciprocal regulation of the neural and innate immune systems
TLDR
CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases.
Why sleep is important for health: a psychoneuroimmunology perspective.
  • M. Irwin
  • Medicine, Psychology
    Annual review of psychology
  • 5 January 2015
TLDR
The impact of sleep on adaptive and innate immunity, with consideration of the dynamics of sleep disturbance, sleep restriction, and insomnia on antiviral immune responses with consequences for vaccine responses and infectious disease risk and proinflammatoryimmune responses with implications for cardiovascular disease, cancer, and depression is highlighted.
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