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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
TLDR
Evidence is presented that delta-like 4 (Dll4)–Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina, and modulators of Dll4 or Notch signalling, such as γ-secretase inhibitors developed for Alzheimer's disease, might find usage as pharmacological regulators of angiogenesis. Expand
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
TLDR
It is demonstrated that VEGF bioavailability is regulated extracellularly by matrix metalloproteinases (MMPs) through intramolecular processing, and it is revealed that a subset of MMPs can cleave matrix-bound isoforms of V EGF, releasing soluble fragments. Expand
Myc-driven murine prostate cancer shares molecular features with human prostate tumors.
TLDR
To define Myc's functional role, transgenic mice expressing human c-Myc in the mouse prostate are generated and this approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases. Expand
Fate tracing reveals the endothelial origin of hematopoietic stem cells.
TLDR
The genetic tracing strategy reveals an endothelial origin of HSCs, as ex vivo analyses demonstrate lack of VE-cadherin Cre induction in circulating and fetal liver hematopoietic populations. Expand
Autocrine VEGF Signaling Is Required for Vascular Homeostasis
TLDR
A cell-autonomous VEGF signaling pathway that holds significance for vascular homeostasis but is dispensable for the angiogenic cascade is revealed. Expand
METH-1, a Human Ortholog of ADAMTS-1, and METH-2 Are Members of a New Family of Proteins with Angio-inhibitory Activity*
TLDR
It is proposed that METH-1 and M ETH-2 represent a new family of proteins with metalloprotease, disintegrin, and thrombospondin domains, and the distinct distribution of each gene product suggests that each has evolved distinct regulatory mechanisms that potentially allow for fine control of activity during distinct physiological and pathological states. Expand
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
TLDR
Reduction of endothelial miRNAs by cell-specific inactivation of Dicer reduces postnatal angiogenic response to a variety of stimuli, including exogenous VEGF, tumors, limb ischemia, and wound healing. Expand
Versican V1 Proteolysis in Human Aorta in Vivo Occurs at the Glu441-Ala442 Bond, a Site That Is Cleaved by Recombinant ADAMTS-1 and ADAMTS-4*
TLDR
It is concluded that versican V1 proteolysis in vivocan be catalyzed by one or more members of the ADAMTS family of metalloproteinases. Expand
VE‐Cadherin‐Cre‐recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells
TLDR
The generation of a transgenic mouse line in which expression of Cre‐recombinase is under the regulatory control of the VE‐Cadherin promoter is reported, in which this model showed expression in the adult quiescent vasculature. Expand
ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165*
TLDR
It is demonstrated that ADAMTS1 significantly blocks VEGFR2 phosphorylation with consequent suppression of endothelial cell proliferation and is described as a novel modulator of VEGF bioavailability. Expand
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