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Crucial Role of Granulocytic Myeloid-Derived Suppressor Cells in the Regulation of Central Nervous System Autoimmune Disease
There is a need in autoimmune diseases to uncover the mechanisms involved in the natural resolution of inflammation. In this article, we demonstrate that granulocytic myeloid-derived suppressor cellsExpand
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Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
Neutrophil NETs drive atherosclerosis The buildup of fats, cholesterol, and other substances in arteries causes atherosclerosis, which restricts blood flow and can lead to heart attacks and stroke.Expand
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Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma
Neoangiogenesis has been documented in small cell lung carcinoma (SCLC). In addition, antiangiogenic therapies are being tested in clinical trials that involve SCLC. However, study of the underlyingExpand
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The negative costimulatory molecule PD‐1 modulates the balance between immunity and tolerance via miR‐21
Disruption of the programmed death‐1 (PD‐1) pathway leads to breakdown of peripheral tolerance and initiation of autoimmunity. The molecular pathways that mediate this effect remain largely unknown.Expand
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AB0175 Elimination of Granulocytic Myeloid-Derived Suppressor Cells in Lupus-Prone Mice Due to Ros-Dependent Extracellular Trap Formation
Background Systemic lupus erythematosus (SLE) is characterized by a breakdown of self-tolerance against nuclear Ags leading to inflammation and multi-organ damage1-2. The mechanisms that participateExpand
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Cell-Based Modulation of Autoimmune Responses in Multiple Sclerosis and Experimental Autoimmmune Encephalomyelitis: Therapeutic Implications
Multiple sclerosis (MS) is a prototypic autoimmune inflammatory disorder of the central nervous system (CNS). MS pathogenesis is a complex phenomenon that is influenced by genetic and environmentalExpand
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Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress
Interleukin 17 (IL-17)–producing γδ T cells (γδ17 T cells) have been recently found to promote tumor growth and metastasis formation. How such γδ17 T-cell responses may be regulated in the tumorExpand
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Elimination of Granulocytic Myeloid‐Derived Suppressor Cells in Lupus‐Prone Mice Linked to Reactive Oxygen Species–Dependent Extracellular Trap Formation
Emerging evidence supports a crucial role of myeloid‐derived suppressor cells (MDSCs) in the regulation of autoimmune diseases. However, their role in systemic lupus erythematosus (SLE) remainsExpand
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In Vivo Ablation of Plasmacytoid Dendritic Cells Inhibits Autoimmunity through Expansion of Myeloid-Derived Suppressor Cells
Autoimmunity ensues upon breakdown of tolerance mechanism and priming of self-reactive T cells. Plasmacytoid dendritic cells (pDCs) constitute a unique cell subset that participates in the activationExpand
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De Novo–Induced Self-Antigen–Specific Foxp3+ Regulatory T Cells Impair the Accumulation of Inflammatory Dendritic Cells in Draining Lymph Nodes
Foxp3+ regulatory T cell (Treg)-based immunotherapy holds promise for autoimmune diseases. However, this effort has been hampered by major caveats, including the low frequency of autoantigen-specificExpand
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