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Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolicallyExpand
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Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
Lysophosphatidic acid (LPA) is a bioactive lipid with activity in the nervous system mediated by G-protein-coupled receptors. Here, we examined the role of LPA signaling in the development ofExpand
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Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
Characterization of an animal model may explain why not all patients with multiple sclerosis respond to interferon-β. Inflammasome Dependency Determines Therapy? Multiple sclerosis (MS) is anExpand
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Structural Basis for Sequence-specific DNA Recognition by an Arabidopsis WRKY Transcription Factor*
Background: The WRKY transcription factors recognize the W-box DNA element in target genes. Results: We determined the NMR solution structure of the WRKY DNA-binding domain of Arabidopsis WRKY4 inExpand
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Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
Stimulation of resting CD4+ T lymphocytes leads to rapid proliferation and differentiation into effector (Teff) or inducible regulatory (Treg) subsets with specific functions to promote or suppressExpand
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NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis
The NLRP3 inflammasome is a multiprotein complex consisting of three kinds of proteins, NLRP3, ASC, and pro-caspase-1, and plays a role in sensing pathogens and danger signals in the innate immuneExpand
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Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia.
BACKGROUND The clinical efficacy of dopamine D2 receptor antagonism on the psychotic symptoms of schizophrenia has been widely demonstrated. However, most in vivo imaging studies have not been ableExpand
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Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors
After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs without foreign gene insertions. Here weExpand
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Angiotensin II Type 1 Receptor–Mediated Inflammation Is Required for Choroidal Neovascularization
Background—Choroidal neovascularization (CNV) is a critical pathogenesis in age-related macular degeneration, the most common cause of blindness in the developed countries. The aim of the currentExpand
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Loss of Peripheral Morphine Analgesia Contributes to the Reduced Effectiveness of Systemic Morphine in Neuropathic Pain
It is well known that the analgesic potency of morphine is reduced in neuropathic pain. In this study, we demonstrate that the decreased effectiveness of systemic morphine in neuropathic pain mightExpand
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