M. Inoue

Publications213
h-index36
Citations5,059
Highly Influential Citations188
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Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
TLDR
Analysis of CD4+ T cell populations in murine models and metabolic profiling revealed that pyruvate dehydrogenase (PDH) is a key bifurcation point between T cell glycolytic and oxidative metabolism, showing that CD4- subsets utilize and require distinct metabolic programs that can be targeted to control specific Tcell populations in autoimmune and inflammatory diseases.
Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
TLDR
It is demonstrated that signaling by IFNAR on macrophages inhibits activation of Rac1 and the generation of reactive oxygen species (ROS) through suppressor of cytokine signaling 1 (SOCS1) and suppressed the activity of the Nod-like receptor family, pyrin domain–containing 3 (NLRP3) inflammasome, which resulted in attenuated EAE pathogenicity.
Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors
TLDR
It is shown that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs and suggested that generation of transgene-free iPSCS from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future.
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis
TLDR
It is found that the NLRP3 inflammasome played a critical role in inducing T-helper cell migration into the CNS and targeting immune cell migration molecules may be an effective approach in treating MS accompanied by NLRP2 inflammaome activation.
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
TLDR
In vivo inhibition of ERRα reduced T-cell proliferation and Teff generation in both immunization and experimental autoimmune encephalomyelitis models, suggesting that ERR α is a selective transcriptional regulator of Teff metabolism that may provide a metabolic means to modulate immunity.
Microtubule acetylation amplifies p38 kinase signaling and anti-inflammatory IL-10 production
TLDR
It is reported that macrophages challenged by bacterial lipopolysaccharides (LPS) undergo extensive microtubule acetylation, identified as a kinase signaling modulator and a key component in the inflammatory response.
Identification of Pendrin as a Common Mediator for Mucus Production in Bronchial Asthma and Chronic Obstructive Pulmonary Disease1
TLDR
It is suggested that pendrin can induce mucus production in airway epithelial cells and may be a therapeutic target candidate for bronchial asthma and COPD.
NLRP3 Inflammasome and MS/EAE
TLDR
The NLRP3 inflammasome in MS and EAE development is discussed and it is shown that the NLRP2 inflammaome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS, although EAE can also develop without the NL RP3 infammasome.
Intracellular osteopontin (iOPN) and immunity
TLDR
iOPN is involved in cytoskeletal rearrangement and in signal transduction pathways downstream of innate immune receptors, such as Toll-like receptors (TLRs), as an adaptor or scaffolding protein.
Role of Activating Transcription Factor 3 (ATF3) in Endoplasmic Reticulum (ER) Stress-induced Sensitization of p53-deficient Human Colon Cancer Cells to Tumor Necrosis Factor (TNF)-related…
TLDR
The results provide novel insights into the role of ATF3 as an essential transcription factor for p53-independent DR5 induction upon both ZER and CCB treatment, and this may be a useful biomarker for TRAIL-based anticancer therapy.
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