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Aminoacyl-RNA synthesis catalyzed by an RNA
An RNA has been selected that rapidly aminoacylates its 2'(3') terminus when provided with phenylalanyl-adenosine monophosphate. That is, the RNA accelerates the same aminoacyl group transferExpand
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A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis.
A 29-nt RNA catalyst successively forms the aminoacyl ester phe-RNA, and then peptidyl-RNA (phe-phe-RNA), given phenylalanine adenylate (phe-AMP) as substrate. Catalysis of two related reactions atExpand
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Affinity selection-amplification from randomized ribooligonucleotide pools.
Publisher Summary Selection-amplification introduced a new capability to the study of RNA and DNA. One could ask if any nucleic acid (less than a certain size) existed that could perform a particularExpand
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Catalyzed and spontaneous reactions on ribozyme ribose.
The RNA world hypothesis requires that early translation be catalyzed by RNA enzymes. Here we show that a five-nucleotide RNA enzyme, reacting with a tetranucleotide substrate and elevated PheAMP,Expand
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Specific, rapid synthesis of Phe-RNA by RNA.
RNA 77, derived by selection amplification, accelerates its own conversion to Phe-RNA (relative to randomized RNA) more than 6 x 10(7)-fold, by using amino acid adenylates as substrate. A modifiedExpand
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Circular dichroism studies of distorted α-helices, twisted β-sheets, and β-turns
Theoretical models for calculating the circular dichroism (CD) of biopolymers have been constructed which allow the evaluation of the effects of geometric distortions within regular secondaryExpand
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Small-molecule-substrate interactions with a self-aminoacylating ribozyme.
A self-aminoacylating RNA catalyst is shown to carry out the chemistry required for turnover, being reacylated several times from aminoacyl-AMP with an unaltered rate, thereby meeting one definitionExpand
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Phenylalanine-Binding RNAs and Genetic Code Evolution
We isolated RNAs by selection–amplification, selecting for affinity to Phe–Sepharose and elution with free l-phenylalanine. Constant sequences did not contain Phe condons or anticodons, to avoid anyExpand
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Circular dichroism studies of distorted alpha-helices, twisted beta-sheets, and beta turns.
Theoretical models for calculating the circular dichroism (CD) of biopolymers have been constructed which allow the evaluation of the effects of geometric distortions within regular secondaryExpand
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Poly(U) RNA-templated synthesis of AppA.
Simple nucleotide templating activities are of interest as potential primordial reactions. Here we describe the acceleration of 5'-5' AppA synthesis by 3'-5' poly(U) under normal solution conditions.Expand
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