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Endothelial targeting of antibody-decorated polymeric filomicelles.
The endothelial lining of the lumen of blood vessels is a key therapeutic target for many human diseases. Polymeric filomicelles that self-assemble from polyethylene oxide (PEO)-based diblockExpand
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Stabilization of soft lipid colloids: competing effects of nanoparticle decoration and supported lipid bilayer formation.
Stabilization against fusion of zwitterionic lipid small unilamellar vesicles (SUVs) by charged nanoparticles is essential to prevent premature inactivation and cargo unloading. In the present work,Expand
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Palladium metal nanoparticle size control through ion paired structures of [PdCl4]2- with protonated PDMAEMA.
The mean diameter of palladium metal particles produced by citrate reduction of the (H(+))(n) PDMAEMA/[PdCl(4)](2-) aqueous system increases from 1.4 nm to 5.0 nm as the pH decreases from 6.3 to 3.3Expand
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Formation and colloidal stability of DMPC supported lipid bilayers on SiO2 nanobeads.
Supported lipid bilayers (SLBs) of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) were formed on 20-100 nm silica (SiO(2)) nanobeads, and the formation was accompanied by an 8 nm increase inExpand
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Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener.
Cationic lipids provide a promising alternative to the use of viruses for delivering genes therapeutically. Among the several classes of lipidic vectors, those bearing a heterocyclic cationic headExpand
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Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
Aromatic/heterocyclic sulfonamides act as strong inhibitors of the zinc enzyme carbonic anhydrase (CA; EC 4.2.1.1), but the presently available compounds do not generally discriminate between the 14Expand
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Therapeutic applications of serine protease inhibitors
Serine proteases (SPs) are known to regulate important biological processes, which makes them attractive targets in therapy. In recent years, much effort has been directed to revealing physiologicalExpand
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Supported lipid bilayer nanosystems: stabilization by undulatory-protrusion forces and destabilization by lipid bridging.
Control of the stabilization/destabilization of supported lipid bilayers (SLBs) on nanoparticles is important for promotion of their organized assembly and for their use as delivery vehicles. At theExpand
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Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function
Carbonic anhydrase (CA) plays a key role in neuronal signaling, providing bicarbonate and proton ions for GABAergic and glutamatergic neuronal function. Activation of CA isoforms expressed in neuronsExpand
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Potential learning and memory disruptors and enhancers in a simple, 1-day operant task in mice
The objective of this study was to develop a rapid, 1-day learning and memory assay in mice that is sensitive to the effects of compounds that could impair or enhance acquisition and retrieval.Expand
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