M. Ikura

Publications421
h-index86
Citations31,455
Highly Influential Citations1,529
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Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
Important Ca2+ signals in the cytosol and organelles are often extremely localized and hard to measure. To overcome this problem we have constructed new fluorescent indicators for Ca2+ that are… Expand
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Calmodulin Target Database
The intracellular calcium sensor protein calmodulin (CaM) interacts with a large number of proteins to regulate their biological functions in response to calcium stimulus. This molecular recognition… Expand
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Solution structure of a calmodulin-target peptide complex by multidimensional NMR.
The three-dimensional solution structure of the complex between calcium-bound calmodulin (Ca(2+)-CaM) and a 26-residue synthetic peptide comprising the CaM binding domain (residues 577 to 602) of… Expand
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Calcium-induced conformational transition revealed by the solution structure of apo calmodulin
The solution structure of Ca2+-free calmodulin has been determined by NMR spectroscopy, and is compared to the previously reported structure of the Ca2+-saturated form. The removal of Ca2+ causes the… Expand
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MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli.
Escherichia coli contains operons called "addiction modules," encoding toxin and antitoxin, which are responsible for growth arrest and cell death. Here, we demonstrate that MazF toxin encoded by… Expand
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Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins
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Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.
The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements. Results… Expand
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Molecular and structural basis of target recognition by calmodulin.
  • A. Crivici, M. Ikura
  • Chemistry, Medicine
  • Annual review of biophysics and biomolecular…
  • 1995
Calmodulin (CaM) acts as an intracellular calcium sensor that translates the Ca2+ signal into a variety of cellular processes. Ca(2+)-CaM recognition of a short polypeptide segment in target proteins… Expand
  • 650
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Structural basis of calcium-induced E-cadherin rigidification and dimerization
THE cadherins mediate cell adhesion and play a fundamental role in normal development1. They participate in the maintenance of proper cell–cell contacts: for example, reduced levels of epithelial… Expand
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Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins. 1990.
correlates the amide ‘H and “N shifts with the 13C shift of the carbonyl resonance of the preceding amino acid. A second experiment (HNCA) correlates the intraresidue amide ‘H and 15N shifts with the… Expand
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