M. Ikura

Publications439
h-index89
Citations33,321
Highly Influential Citations1,624
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Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
TLDR
New fluorescent indicators for Ca2+ that are genetically encoded without cofactors and are targetable to specific intracellular locations are constructed and dubbed ‘cameleons’.
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Calmodulin Target Database
TLDR
A web-based database is developed that can predict a putative CRS location within a given protein sequence, identify the subclass to which it may belong, and structural and biophysical parameters such as hydrophobicity, hydrophobic moment, and propensity for a -helix formation.
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Solution structure of a calmodulin-target peptide complex by multidimensional NMR.
The three-dimensional solution structure of the complex between calcium-bound calmodulin (Ca(2+)-CaM) and a 26-residue synthetic peptide comprising the CaM binding domain (residues 577 to 602) of…
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Calcium-induced conformational transition revealed by the solution structure of apo calmodulin
TLDR
The solution structure of Ca2-free calmodulin has been determined by NMR spectroscopy, and is compared to the previously reported structure of the Ca2+-saturated form, and concerted movements of helices A and D with respect to B and C, are likely responsible for the cooperative Ca2+,binding property observed between two adjacent EF-hand sites in the amino- and carboxy-terminal domains.
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Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins
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Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.
TLDR
The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements, showing a high degree of mobility near the middle of the central helix and anisotropy observed in the motion of the two globular cal modulin domains is much smaller than expected.
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Molecular and structural basis of target recognition by calmodulin.
TLDR
The structural aspects of target recognition by Ca(2+)-CaM are discussed using mainly the three-dimensional structural information obtained with nuclear magnetic resonance spectroscopy and X-ray diffraction methods.
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Structural basis of calcium-induced E-cadherin rigidification and dimerization
TLDR
The E-cadherin dual-domain structure reported here defines the role played by calcium in the cadherin-mediated formation and maintenance of solid tissues.
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MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli.
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Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins. 1990.
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