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Role of metabolism in the selectivity of a herbicide, pyroxasulfone, between wheat and rigid ryegrass seedlings
Metabolism of pyroxasulfone in a tolerant crop, wheat and a susceptible plant, rigid ryegrass, was studied using 14C-pyroxasulfone. The main metabolites were a cysteine conjugate of the isoxazolineExpand
Inhibitory effect of carbon monoxide on the hydroxylation of testosterone by rat liver microsomes.
TLDR
The results obtained suggest that one or more CO-binding cytochromes function in the hydroxylation of testosterone by rat liver microsomes. Expand
The metabolism of styrene in the rat and the stimulatory effect of phenobarbital.
  • H. Otsuji, M. Ikeda
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1 February 1971
TLDR
The results together with those from previous studies support the following pathway of styrene metabolism in the rat: the metabolism proceeds through the oxidative conversion to a more toxic compound. Expand
Stimulatory effect of phenobarbital and insecticides on warfarin metabolism in the rat.
TLDR
The stimulatory effect of phenobarbital on warfarin metabolism in the rat offers an explanation for the observations of others indicating that phenobarBital decreases the anticoagulant action of warFarin in man. Expand
Degradation of the herbicide orbencarb in Soils
14C-オルベンカルブを用い, 種々の土壌条件下での分解を室内実験により検討した, オルベンカルブは湛水条件よりも畑地条件で速やかに分解した. 滅菌土壌での分解は遅かった. オルベンカルブの半減期は供試した3種類の土壌で18~26日であり, 炭酸ガスが顕著に生成した. 主要な分解物として orbencarb sulfoxlde, monodesethyl-orbencarb, methylExpand
Phenobarbital-induced protection against toxicity of toluene and benzene in the rat.
  • M. Ikeda, H. Otsuji
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1 September 1971
TLDR
Rapid disappearance of toLUene from blood due to enhanced hepatic metabolism together with reduced sensitivity of central nervous system offer an explanation for the shortened sleeping time after toluene injection. Expand
In vivo suppression of benzene and styrene oxidation by co-administered toluene in rats and effects of phenobarbital.
TLDR
Biotransformations of benzene to phenol, and styrene to phenylglyoxylic acid, mandelic acid and hippuric acid were suppressed by co-administration of toluene; the induction of oxidative activities in the liver, with phenobarbital, alleviated the suppression. Expand
A sensitive method for the determination and isolation of pentobarbital-C14 metabolites and its application to in vitro studies of drug metabolism.
TLDR
It is shown that the metabolism of pentobarbital is stimulated by chronic phenobarbitals treatment and that the l -alcohol metabolite of pentbarbital can be further metabolized by an enzyme system present in the 100,000 x g supernatant fraction of liver which requires nicotinamide adenine dinucleotide for activity. Expand
Comparative studies on aniline hydroxylation and p-nitrotoluene hydroxylation by the liver.
TLDR
An attempt is made to justify the hypothesis that multiple oxidative enzymes are present in hepatic microsomes by comparative studies on hepatic activities between sexes and species of rodents as well as on the effects of inducers and inhibitors on the kinetics of the two hydroxylation activities. Expand
Comparative studies on hepatic N- and O-demethylation.
TLDR
Oxidative dealkylation is an important step in the metabolism of various foreign compounds including a number of clinically useful drugs and microsomal oxidative reactions, i.e., N- and O-demethylation, the two possible variations of hydroxylation are studied. Expand
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