M. Iinuma

Publications464
h-index53
Citations11,876
Highly Influential Citations293
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Antibacterial Activity of Xanthones from Guttiferaeous Plants against Methicillin‐resistant Staphylococcus aureus
Extracts of Garcinia mangostana (Guttiferae) showing inhibitory effects against the growth of S. aureus NIHJ 209p were fractionated according to guidance obtained from bioassay and some of the…
Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus.
Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics.
Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen
TLDR
A mechanism of α-mangostin-induced growth inhibition in DLD-1 cells is focused on, which could provide a relevant basis for the development of xanthones as an agent for cancer prevention and the combination therapy with anti-cancer drugs.
Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines.
TLDR
The growth inhibitory effects of isogarcinol and xanthochymol were more potent than that of garcinol, which is a well- known cytotoxic benzophenone derivative.
Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells.
Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal…
Flavones with antibacterial activity against cariogenic bacteria.
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
TLDR
Six xanthones from the pericarps of mangosteen, Garcinia mangostana, showed growth inhibitory effects of human leukemia cell line HL60, and alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat.
TLDR
The finding that crude alpha-mangostin has potent chemopreventive effects in the authors' short-term colon carcinogenesis bioassay system suggests that longer exposure might result in suppression of tumor development.
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