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White Matter Lesions and Glial Activation in a Novel Mouse Model of Chronic Cerebral Hypoperfusion
TLDR
WM lesions were successfully induced after chronic cerebral hypoperfusion with relative preservation of the visual pathway and features in this mouse model are appropriate for cognitive assessment and genetic analysis, and it may provide a powerful tool to understand the pathophysiology of WM lesions.
A Mouse Model Characterizing Features of Vascular Dementia With Hippocampal Atrophy
TLDR
The results suggest that the longer-term BCAS model replicates advanced stages of subcortical ischemic vascular dementia when hippocampal neuronal loss becomes significant.
Selective Impairment of Working Memory in a Mouse Model of Chronic Cerebral Hypoperfusion
TLDR
Working memory deficits as well as white matter changes were apparent in the mice, suggesting the BCAS model is useful to evaluate the substrates of subcortical vascular dementia.
Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor
TLDR
It is demonstrated that, during endogenous recovery from white matter damage, astrocytes may promote oligodendrogenesis by secreting brain-derived neurotrophic factor (BDNF), which would be broadly and clinically applicable to CNS disease.
A Novel Mouse Model of Subcortical Infarcts with Dementia
TLDR
A novel animal model of WM infarct damage with cognitive impairment can be generated by surgical implantation of different devices to the right and left common carotid artery in C57BL/6J mice, which replicates the phenotypes of human subcortical VCI.
Stroke injury, cognitive impairment and vascular dementia☆
Does vascular pathology contribute to Alzheimer changes?
SILENT ISCHEMIC INFARCTS ARE ASSOCIATED WITH HEMORRHAGE BURDEN IN CEREBRAL AMYLOID ANGIOPATHY
1. Yuan RY, Sheu JJ, Yu JM, et al. Botulinum toxin for diabetic neuropathic pain: a randomized double-blind crossover trial. Neurology 2009;72:1473–1478. 2. Apfel SC. Botulinum toxin for neuropathic
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