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- Publications
- Influence
White Matter Lesions and Glial Activation in a Novel Mouse Model of Chronic Cerebral Hypoperfusion
- Masunari Shibata, R. Ohtani, M. Ihara, H. Tomimoto
- Medicine
- Stroke
- 1 November 2004
Background and Purpose— Cerebrovascular white matter (WM) lesions are closely associated with cognitive impairment and gait disorders in the elderly. We have successfully established a mouse model of… Expand
Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa.
- M. Ihara, A. Kinoshita, +12 authors M. Kinoshita
- Biology, Medicine
- Developmental cell
- 1 March 2005
Septins are polymerizing GTP binding proteins required for cortical organization during cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed mainly in postmitotic… Expand
Selective Impairment of Working Memory in a Mouse Model of Chronic Cerebral Hypoperfusion
- Masunari Shibata, N. Yamasaki, +6 authors H. Tomimoto
- Medicine
- Stroke
- 1 October 2007
Background and Purpose— We recently designed a mouse model of chronic cerebral hypoperfusion, in which the cerebral white matter is damaged without significant gray matter lesions. The behavioral… Expand
Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor
- N. Miyamoto, T. Maki, +8 authors K. Arai
- Biology, Medicine
- The Journal of Neuroscience
- 14 October 2015
Oligodendrocyte precursor cells (OPCs) in the adult brain contribute to white matter homeostasis. After white matter damage, OPCs compensate for oligodendrocyte loss by differentiating into mature… Expand
SILENT ISCHEMIC INFARCTS ARE ASSOCIATED WITH HEMORRHAGE BURDEN IN CEREBRAL AMYLOID ANGIOPATHY
- Yoko Okamoto, M. Ihara, H. Tomimoto
- Medicine
- Neurology
- 5 January 2010
1. Yuan RY, Sheu JJ, Yu JM, et al. Botulinum toxin for diabetic neuropathic pain: a randomized double-blind crossover trial. Neurology 2009;72:1473–1478. 2. Apfel SC. Botulinum toxin for neuropathic… Expand
Does vascular pathology contribute to Alzheimer changes?
- R. Kalaria, R. Akinyemi, M. Ihara
- Medicine
- Journal of the Neurological Sciences
- 15 November 2012
In recent years there has been increased interest in whether vascular disease contributes to Alzheimer's disease (AD). This review considers how modifiable risk factors such as hypertension,… Expand
A Mouse Model Characterizing Features of Vascular Dementia With Hippocampal Atrophy
- K. Nishio, M. Ihara, +9 authors H. Tomimoto
- Medicine
- Stroke
- 1 June 2010
Background and Purpose— We have previously described effects of chronic cerebral hypoperfusion in mice with bilateral common carotid artery stenosis (BCAS) using microcoils for 30 days. These mice… Expand
A Novel Mouse Model of Subcortical Infarcts with Dementia
- Yorito Hattori, J. Enmi, +9 authors M. Ihara
- Psychology, Medicine
- The Journal of Neuroscience
- 4 March 2015
Subcortical white matter (WM) is a frequent target of ischemic injury and extensive WM lesions are important substrates of vascular cognitive impairment (VCI) in humans. However, ischemic stroke… Expand
Sept4, a Component of Presynaptic Scaffold and Lewy Bodies, Is Required for the Suppression of α-Synuclein Neurotoxicity
- M. Ihara, N. Yamasaki, +10 authors M. Kinoshita
- Biology, Medicine
- Neuron
- 15 February 2007
In Parkinson disease (PD), alpha-synuclein aggregates called Lewy bodies often involve and sequester Septin4 (Sept4), a polymerizing scaffold protein. However, the pathophysiological significance of… Expand
Association of the Cytoskeletal GTP-binding Protein Sept4/H5 with Cytoplasmic Inclusions Found in Parkinson's Disease and Other Synucleinopathies*
- M. Ihara, H. Tomimoto, +5 authors M. Kinoshita
- Biology, Medicine
- Journal of Biological Chemistry
- 27 June 2003
α-Synuclein-positive cytoplasmic inclusions are a pathological hallmark of several neurodegenerative disorders including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.… Expand