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Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohn's disease
Background: Oxidative stress is considered a potential etiological factor for Crohn's disease (CD). We characterized the reactive oxygen species (ROS) generated in immune peripheral cells of CD… Expand
Identification of serum and tissue micro‐RNA expression profiles in different stages of inflammatory bowel disease
- M. Iborra, F. Bernuzzi, +9 authors S. Danese
- Biology, Medicine
- Clinical and experimental immunology
- 1 August 2013
The altered expression of micro‐RNA (miRNA) has been associated with Crohn's disease (CD) and ulcerative colitis (UC). The aim of this study was to establish specific miRNA expression patterns in the… Expand
Incidence, Clinical Characteristics, and Management of Psoriasis Induced by Anti-TNF Therapy in Patients with Inflammatory Bowel Disease: A Nationwide Cohort Study
- I. Guerra, Tamara Pérez-Jeldres, +28 authors J. Gisbert
- Inflammatory bowel diseases
- 1 April 2016
Background:Psoriasis induced by anti–tumor necrosis factor-&agr; (TNF) therapy has been described as a paradoxical side effect. Aim:To determine the incidence, clinical characteristics, and… Expand
Assessing an Improved Protocol for Plasma microRNA Extraction
The first step in biomarkers discovery is to identify the best protocols for their purification and analysis. This issue is critical when considering peripheral blood samples (plasma and serum) that… Expand
Role of oxidative stress and antioxidant enzymes in Crohn's disease.
- M. Iborra, I. Moret, +5 authors B. Beltrán
- Biology, Medicine
- Biochemical Society transactions
- 1 August 2011
There is increasing interest in oxidative stress being a potential aetiological factor and/or a triggering factor in Crohn's disease, rather than a concomitant occurrence during the pathogenesis of… Expand
Two strategies for family intervention in schizophrenia: a randomized trial in a Mediterranean environment.
Controlled intervention studies carried out in families of schizophrenia patients have been shown to have a positive impact in relapse prevention, but it remains to be seen whether different forms of… Expand
Infliximab and adalimumab-induced psoriasis in Crohn's disease: a paradoxical side effect.
Treatment with antitumor necrosis factor-alpha (anti-TNF-α) offers a significant improvement in several immune-based diseases, including Crohn's disease (CD) and psoriasis. Different cutaneous side… Expand
Immunological Mechanisms of Adsorptive Cytapheresis in Inflammatory Bowel Disease
- E. Sáez-González, I. Moret, +5 authors B. Beltrán
- Digestive Diseases and Sciences
- 21 April 2017
Ulcerative colitis and Crohn’s disease are the two main forms of inflammatory bowel disease (IBD). The study of immunological pathways involved in the onset of IBD is of fundamental importance to… Expand
MicroRNAs in autoimmunity and inflammatory bowel disease: crucial regulators in immune response.
MicroRNAs (miRNAs) have recently emerged as a new class of modulators of gene expression at the post-transcriptional level. The function of miRNA is the control of protein production by targeting… Expand
Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients.
AIM To evaluate the effectiveness of adalimumab in preventing recurrence after intestinal resection for Crohn's disease in high-risk patients. METHODS A multicenter, prospective, observational… Expand