• Publications
  • Influence
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer’s disease
Mechanisms for the involvement of the NMDA receptor complex and its interaction with polyamines in the pathogenesis of AD are discussed andNMDA receptor antagonists have potential for the therapeutic amelioration of AD. Expand
Biochemical and molecular studies using human autopsy brain tissue
It is concluded that valid and practical measures of a variety of parameters may be made in human brain tissue, provided that specific factors are controlled. Expand
Low-density neuronal networks cultured using patterned poly-l-lysine on microelectrode arrays
  • S. Jun, M. Hynd, +4 authors S. Kim
  • Biology, Medicine
  • Journal of Neuroscience Methods
  • 15 March 2007
Application of DNQX, an AMPA antagonist, blocked all spontaneous activity, suggesting that the activity is excitatory and mediated through glutamate receptors. Expand
Release of nerve growth factor from HEMA hydrogel-coated substrates and its effect on the differentiation of neural cells.
It is proposed that local delivery of neurotrophins would enhance neuron survival and promote neuron sprouting toward device electrodes, thus providing improved electrode-neuron communication and device performance for recording and stimulating CNS activity. Expand
Applications of hydrogels for neural cell engineering
The use of acrylate-based polymers and their derivatives, for use in biomedical applications, including drug delivery, tissue engineering, cell encapsulation, and as templates for directed cell growth, attachment and proliferation are discussed. Expand
Differential expression of N‐methyl‐d‐aspartate receptor NR2 isoforms in Alzheimer's disease
The results suggest that NR2 subunit composition may modulate NMDA receptor‐mediated excitotoxicity and might give rise to the regionally selective pattern of neuronal loss that is characteristic of AD. Expand
Fabrication and optimization of alginate hydrogel constructs for use in 3D neural cell culture.
A 3D culture system has been developed using alginate as a cell scaffold, capable of maintaining the viability and function of a variety of neural cell types, and characterized in terms of their biochemical and biomechanical properties, effects on seeded neural cells, and suitability for use as 3D neural cell culture models. Expand
Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease
Cell that express NR1 subunits with the N‐terminal cassette may be selectively vulnerable to toxicity in AD, and the population profile of NR1 transcripts in occipital cortex differed from the profiles in other brain regions studied. Expand
Effects of Glial Cells on Electrode Impedance Recorded from Neural Prosthetic Devices In Vitro
An in vitro system in which cell conditions can be varied within an artificial tissue matrix surrounding a neural prosthetic device is designed in which the effects of glial cell type on electrode impedance to be determined. Expand
Three-dimensional hydrogel cultures for modeling changes in tissue impedance around microfabricated neural probes.
This study demonstrates the utility of the in vitro culture system by demonstrating that differences in cell density within the three-dimensional alginate constructs result in differences in resistance and capacitance as measured by electrochemical impedance spectroscopy. Expand