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Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.
Recently, the relationship of mitochondrial DNA (mtDNA) variants to metabolic risk factors for diabetes and other common diseases has begun to attract increasing attention. However, progress in thisExpand
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Prevalence of asymptomatic ST segment elevation in right precordial leads with right bundle branch block (Brugada-type ST shift) among the general Japanese population
OBJECTIVE To examine the modality and morbidity of asymptomatic ST segment elevation in leads V1 to V3 with right bundle branch block (Brugada-type ST shift). METHODS 8612 Japanese subjects (5987 menExpand
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Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle.
We investigated the effect of fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, on insulin sensitivity including lipid metabolism in skeletal muscle. Six-week-old maleExpand
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Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-γ dependent pathway
Objectives Telmisartan is an angiotensin II receptor blocker and selective modulator of peroxisome proliferator-activated receptor-γ reported to increase energy expenditure and improve glucose andExpand
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Tissue-specific impairment of insulin signaling in vasculature and skeletal muscle of fructose-fed rats.
The relation between insulin resistance/hyperinsulinemia and cardiovascular diseases has attracted much attention. Insulin affects not only glucose metabolism, but also protein synthesis and cellExpand
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Olmesartan Ameliorates Insulin Sensitivity by Modulating Tumor Necrosis Factor-α and Cyclic AMP in Skeletal Muscle
We have reported that tumor necrosis factor (TNF)-α in skeletal muscle is one of the determinants of insulin resistance and that the renin-angiotensin system may be related to the regulation of TNF-αExpand
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The effect of tumor necrosis factor-alpha on tissue specificity and selectivity to insulin signaling.
Recent studies have indicated that tumor necrosis factor (TNF)-alpha plays a significant role in insulin resistance. It has been proposed that selective impairment of insulin signaling in glucoseExpand
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Low Adiponectin Level in Young Normotensive Men with a Family History of Essential Hypertension
Circulating level of adiponectin, an adipocyte-derived protein, is reduced in states of insulin resistance such as obesity and type 2 diabetes. We have previously shown that hypoadiponectinemia isExpand
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2 diabetes in conplastic strains Direct linkage of mitochondrial genome variation to risk factors for data
Access the most recent version at doi: 2007 17: 1319-1326; originally published online Aug 10, 2007; Genome Res. Sugimoto and Theodore Kurtz Tomas Mracek, Ludmila Kazdova, Olena Oliyarnyk, JiamingExpand