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The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. The ability to alter substrate oxidation in response toExpand
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A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.
Obesity and type 2 diabetes have been associated with a high-fat diet (HFD) and reduced mitochondrial mass and function. We hypothesized a HFD may affect expression of genes involved in mitochondrialExpand
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Adiponectin is not altered with exercise training despite enhanced insulin action.
  • M. Hulver, D. Zheng, +7 authors G. Dohm
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 1 October 2002
Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin isExpand
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Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*
Obesity and metabolic syndrome are associated with mitochondrial dysfunction and deranged regulation of metabolic genes. Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) is aExpand
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Skeletal muscle lipid metabolism with obesity.
The objectives of this study were to 1). examine skeletal muscle fatty acid oxidation in individuals with varying degrees of adiposity and 2). determine the relationship between skeletal muscle fattyExpand
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UCP1-independent Thermogenesis in White Adipose Tissue of Cold-acclimated Ucp1-/- Mice*
Apart from UCP1-based nonshivering thermogenesis in brown adipocytes, the identity of thermogenic mechanisms that can be activated to reduce a positive energy balance is largely unknown. To identifyExpand
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Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting.
OBJECTIVE Alternate day fasting may extend lifespan in rodents and is feasible for short periods in nonobese humans. The aim of this study was to examine the effects of 3 weeks of alternate dayExpand
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Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans.
Obesity and type 2 diabetes are strongly associated with abnormal lipid metabolism and accumulation of intramyocellular triacylglycerol, but the underlying cause of these perturbations are yetExpand
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Role of adiponectin in human skeletal muscle bioenergetics.
Insulin resistance is associated with impaired skeletal muscle oxidation capacity and reduced mitochondrial number and function. Here, we report that adiponectin signaling regulates mitochondrialExpand
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Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy.
MicroRNAs modulate cellular phenotypes by inhibiting expression of mRNA targets. In this study, we have shown that the muscle-specific microRNAs miR-133a-1 and miR-133a-2 are essential for multipleExpand
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