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Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn's disease using the nested polymerase chain reaction
TLDR
The high prevalence of coexistent HHV6 infection with either or both of these two viruses in ulcerative colitis tissue suggests that they may play a synergistic role in the pathogenesis of this disease. Expand
Nocturnal intragastric acidity during and after a period of dosing with either ranitidine or omeprazole.
TLDR
It is concluded that rebound intragastric hyperacidity after dosing with 300 mg ranitidine at night or sustained hypoacidityafter doses with 40 mg omeprazole every morning reflect transient disturbances of gastric function that are unlikely to be of clinical importance. Expand
Thrombotic vascular risk factors in inflammatory bowel disease.
TLDR
In many young patients with inflammatory bowel disease, plasma concentrations of these prothrombotic factors were in excess of the limits that are regarded as posing an increased risk for the development of occlusive vascular disease. Expand
Eradication of Helicobacter pylori abolishes 24‐hour hypergastrinaemia: a prospective study in healthy subjects
TLDR
It is concluded that H. pylori infection is associated with 24‐hour hypergastrinaemia, and that in apparently healthy subjects normal gastric physiology can be restored by eradication of the infection. Expand
Tolerance during 5 months of dosing with ranitidine, 150 mg nightly: a placebo-controlled, double-blind study.
TLDR
Tolerance does develop in healthy subjects during the first month of dosing with ranitidine, 150 mg nightly, but it is not a progressive phenomenon, and it is probably not of clinical relevance. Expand
Transmucosal penetration of bismuth particles in the human stomach.
TLDR
Persorption of bismuth particles through the gastric mucosa to the vascular endothelium provides an explanation for the rapid rise of plasma bism Ruth concentration observed only after oral dosing with tripotassium dicitrato bismUTHate. Expand
The effect of ranitidine, cimetidine or famotidine on low‐dose post‐prandial alcohol absorption
TLDR
It is shown that post‐prandial alcohol absorption after 0.3 g/kg of alcohol is not affected by ranitidine, cimetidine or famotidine, and there was no significant difference between the control and post‐dosing studies in the integrated 4‐h plasma alcohol concentration, peak plasmaalcohol concentration, or time to reach peak alcohol concentration. Expand
Crohn's disease and anastomotic recurrence: microvascular ischaemia and anastomotic healing in an animal model
TLDR
The combination of two self‐limiting ischaemic insults can produce a pattern of intestinal inflammation similar to that seen in anastomotic recurrence in Crohn's disease. Expand
Measles virus induction of human endothelial cell tissue factor procoagulant activity in vitro.
TLDR
The capacity of measles virus to induce endothelial tissue factor in vitro, may be relevant to the thrombotic vasculopathy associated with measles virus infection in vivo. Expand
Serum concentrations of von Willebrand factor and soluble thrombomodulin indicate alteration of endothelial function in inflammatory bowel diseases
TLDR
Results indicate alteration of endothelial function in inflammatory intestinal disorders, and may be compatible with the presence of localized vasculitis, but indicate that systemic endothelial destruction does not occur in inflammatory bowel disease. Expand
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