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Origins and functional impact of copy number variation in the human genome
Structural variations of DNA greater than 1 kilobase in size account for most bases that vary among human genomes, but are still relatively under-ascertained. Here we use tiling oligonucleotideExpand
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Molecular characterization of the tumor microenvironment in breast cancer.
Here we describe the comprehensive gene expression profiles of each cell type composing normal breast tissue and in situ and invasive breast carcinomas using serial analysis of gene expression. BasedExpand
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Persistent sulfate formation from London Fog to Chinese haze
Significance Exceedingly high levels of fine particulate matter (PM) occur frequently in China, but the mechanism of severe haze formation remains unclear. From atmospheric measurements in twoExpand
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Elucidating severe urban haze formation in China
  • S. Guo, M. Hu, +9 authors R. Zhang
  • Geography, Medicine
  • Proceedings of the National Academy of Sciences
  • 24 November 2014
Significance We illustrate the similarity and difference in particulate matter (PM) formation between Beijing and other world regions. The periodic cycle of PM events in Beijing is regulated byExpand
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A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes
Defective Gene Detective Identifying genes that give rise to diseases is one of the major goals of sequencing human genomes. However, putative loss-of-function genes, which are often some of theExpand
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Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde
The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinatesExpand
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Formation of urban fine particulate matter.
Urban air pollution represents one of the greatest environmental challenges facing mankind in the 21st century. Noticeably, many developing countries, such as China and India, have experienced severeExpand
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Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14
The ubiquitin‐specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. Mammalian USP14 (Ubp6 in yeast) is unique among known UBPExpand
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PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling
TGFbeta signaling controls diverse normal developmental processes and pathogenesis of diseases including cancer and autoimmune and fibrotic diseases. TGFbeta responses are generally mediated throughExpand
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Particle number size distribution in the urban atmosphere of Beijing, China
Abstract Two-year measurements of particle number size distribution (3 nm–10 μm) were conducted in Beijing, China since March 2004. Their seasonal, weekly and diurnal variations and dependencies onExpand
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