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Spinal Serum-Inducible and Glucocorticoid-Inducible Kinase 1 Mediates Neuropathic Pain via Kalirin and Downstream PSD-95-Dependent NR2B Phosphorylation in Rats
It is suggested that nerve injury could induce spinal SGK1 phosphorylation that subsequently interacts with and upregulates kalirin to participate in neuropathic pain development via PSD-95–NR2B coupling-dependent NR2Bosphorylation.
Melatonin impedes Tet1‐dependent mGluR5 promoter demethylation to relieve pain
It is shown that spinal Tet1 gene transfer by intrathecal delivery of Tet1‐encoding vectors to naïve rats produced profound and long‐lasting nociceptive hypersensitivity and melatonin relieves pain by impeding Tet1-dependent demethylation of mGluR5 in dorsal horn neurons through the MT2 receptor.
Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression
Depression-like behavior is associated with remarkable reduction in glutamatergic, but not GABAergic, transmission in the vlPAG, and this cellular mechanism may be a critical component in the pathogenesis of stress-associated neuropsychiatric disorders.
Bromodomain-containing Protein 4 Activates Voltage-gated Sodium Channel 1.7 Transcription in Dorsal Root Ganglia Neurons to Mediate Thermal Hyperalgesia in Rats
Complete Freund’s adjuvant triggers enhanced bromodomain-containing protein 4 expression, ultimately leading to the enhanced excitability of nociceptive neurons and thermal hyperalgesia.
EphrinB2 induces pelvic-urethra reflex potentiation via Src kinase-dependent tyrosine phosphorylation of NR2B.
The results suggest the ephrinB2-dependent EphBR activation, which subsequently provokes Src kinase-mediated N-methyl-d-aspartate receptor NR2B phosphorylation in the lumbosacral dorsal horn, is crucial for the induction of spinal reflex potentiation contributing to the development of visceral pain and/or hyperalgesia in the pelvic area.
Melatonin relieves neuropathic allodynia through spinal MT2‐enhanced PP2Ac and downstream HDAC4 shuttling‐dependent epigenetic modification of hmgb1 transcription
Melatonin (MLT; N‐acetyl‐5‐methoxytryptamine) exhibits analgesic properties in chronic pain conditions. While researches linking MLT to epigenetic mechanisms have grown exponentially over recent
Neuropathic Allodynia Involves Spinal Neurexin-1&bgr;-dependent Neuroligin-1/Postsynaptic Density-95/NR2B Cascade in Rats
SNL-induced allodynia, which is mediated by the spinal NL1/PSD-95/pNR2B cascade, can be prevented by blockade of transsynaptic Nrx1b–NL1 interactions.
Effects of unilateral posterior missing-teeth on the temporomandibular joint and the alignment of cervical atlas
Individuals with unilateral missing teeth had lower articular eminence inclination, smaller cranio-cervical angle, and a lower percentage of the occlusal plane passing through the intersection of the first and second cervical vertebrae.