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New insights into atopic dermatitis.
TLDR
This review summarizes recent progress in the understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies. Expand
Cytokine modulation of atopic dermatitis filaggrin skin expression.
TLDR
Patients with AD have an acquired defect in filaggrin expression that can be modulated by the atopic inflammatory response, and neutralization of IL-4 and IL-13 could improve skin barrier integrity. Expand
Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes 1
TLDR
Skin biopsies from AD and psoriasis patients were analyzed and decreased expression of a constellation of antimicrobial genes occurs as the result of local up-regulation of Th2 cytokines and the lack of elevated amounts of TNF-α and IFN-γ under inflammatory conditions in AD skin. Expand
Structure-Function Relationships among Human Cathelicidin Peptides: Dissociation of Antimicrobial Properties from Host Immunostimulatory Activities
TLDR
DNA microarray analysis and confirmatory protein analysis showed that LL-37 affects the expression of several chemokines and cytokines by keratinocytes, and observations suggest that proteolytic processing may alter the balance between cathelicidin antimicrobial and host immunostimulatory functions. Expand
Cytokine modulation of atopic dermatitis filaggrin skin expression.
TLDR
Patients with AD have an acquired defect in filaggrin expression that can be modulated by the atopic inflammatory response, and neutralization of IL-4 and IL-13 could improve skin barrier integrity. Expand
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6.
TLDR
It is suggested that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism. Expand
Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
TLDR
It is demonstrated that Th2 cytokines enhance VV replication in AD skin by subverting the innate immune response against VV in a STAT-6-dependent manner. Expand
IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis.
TLDR
Evidence is provided that IL-31 expression is associated with CLA(+) T cells and might contribute to the development of AD-induced skin inflammation and pruritus. Expand
IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3.
TLDR
It is suggested that targeting the STAT-1-signaling pathway or suppressor of cytokine signaling expression enhances beta-defensin expression and represents a new therapeutic strategy for reduction of infection in human diseases associated with beta- defensin deficiency. Expand
A PROSPECTIVE, OBSERVATIONAL STUDY OF SOLUBLE FLT-1 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN SEPSIS
TLDR
Blood levels of free VEGF-A and sFLT in patients presenting to the emergency department (ED) with suspected infection were evaluated to assess the relationship of these levels with severity of illness and inflammation and the first report of s FLT as a potential new marker of severity in patients with sepsis is reported. Expand
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