M. Howard

Publications153
h-index60
Citations19,917
Highly Influential Citations629
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A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
TLDR
A specific, high affinity small molecule antagonist to CXCR7 impedes in vivo tumor growth in animal models, validating this new receptor as a target for development of novel cancer therapeutics. Expand
IL-10 inhibits cytokine production by activated macrophages.
TLDR
The potent action of IL-10 on the macrophage, particularly at the level of monokine production, supports an important role for this cytokine not only in the regulation of T cell responses but also in acute inflammatory responses. Expand
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
TLDR
IL-10 may inhibit macrophage accessory cell function which is independent of TCR-class II MHC interactions, as well as inhibits IL-2-induced IFN-gamma production by Th1 cells in an Ag-free system requiring only the presence of accessory cells. Expand
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature
TLDR
It is established that CXCR7 promotes growth of tumors formed from breast and lung cancer cells and enhances experimental lung metastases in immunodeficient as well as immunocompetent mouse models of cancer. Expand
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.
TLDR
Soluble CD38 catalyzed the formation and hydrolysis of cadPR when added to NAD+. Expand
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
TLDR
It is demonstrated that neutrophil chemotaxis to bacterial chemoattractants is dependent on Ca++ mobilization mediated by cyclic ADP-ribose, and CD38 acts as a critical regulator of inflammation and innate immune responses. Expand
Interleukin 10 protects mice from lethal endotoxemia
TLDR
The protective effect of IL-10 was reversed by prior injection of neutralizing anti-IL-10 antibodies, and correlated with a substantial decrease in endotoxin-induced TNF-alpha release, which implicate IL- 10 as a candidate for treatment of bacterial sepsis, and more generally as an effective antiinflammatory reagent. Expand
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells
TLDR
It is indicated that Ag-specific B cells require two signals for mounting a T cell-dependent Ab response and regulation of sIg signaling as a mechanism for controlling self-reactive B cells is identified. Expand
Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice
TLDR
Consistent with the protective role of anti-IL-10 treatment in these experiments, continuous administration of IL-10 from 4 until 38 wk of age accelerated the onset of autoimmunity in NZB/W F1 mice, suggesting that IL- 10 antagonists may be beneficial in the treatment of human systemic lupus erythematosus. Expand
Ly‐1 B (B‐1) cells are the main source of B cell‐derived interleukin 10
TLDR
Since IL 10 is a potent regulator of in vitro immune function, its production by Ly‐1 lineage B (B‐1) cells raises the possibility that this subset of B cells may regulate their own development and/or the function of other immunocompetent cells. Expand
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