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Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein.
Mammalian prion protein (PrP) is a normal cellular protein (PrPc) which through post-translational modification produces the infectious prion protein (PrPsc). We have shown, using mass spectrometry,Expand
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Copper binding to the N-terminal tandem repeat region of mammalian and avian prion protein: structural studies using synthetic peptides.
Using CD spectroscopy we have investigated the effect of Cu2+ on the secondary structure of synthetic peptides Octa4 and Hexa4 corresponding to tetra-repeats of the octapeptide of mammalian PrP andExpand
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Proteomics Analysis of Rat Brain Postsynaptic Density
The postsynaptic density contains multiple protein complexes that together relay the presynaptic neurotransmitter input to the activation of the postsynaptic neuron. In the present study we took twoExpand
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Proteomics of the Injured Rat Sciatic Nerve Reveals Protein Expression Dynamics During Regeneration *
Using proteomics, we investigated the temporal expression profiles of proteins in rat sciatic nerve after experimental crush. Extracts of sciatic nerves collected at 5, 10, and 35 days after injuryExpand
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Discovering oxysterols in plasma: a window on the metabolome.
While the proteome defines the expressed gene products, the metabolome results from reactions controlled by such gene products. Plasma represents an accessible "window" to the metabolome both inExpand
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Intermittent administration of morphine alters protein expression in rat nucleus accumbens
Repeated exposure to drugs of abuse causes time‐dependent neuroadaptive changes in the mesocorticolimbic system of the brain that are considered to underlie the expression of major behavioralExpand
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Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterolss⃞ Published, JLR Papers in Press, January 24, 2007.
In humans, the brain accounts for about 20% of the body's free cholesterol, most of which is synthesized de novo in brain. To maintain cholesterol balance throughout life, cholesterol becomesExpand
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A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls.
Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are increasingly used in research centers, clinical trials, and clinical settings. However, their broad-scale use is hampered by lackExpand
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Targeted lipidomic analysis of oxysterols in the embryonic central nervous system.
In this study two regions of embryonic (E11) mouse central nervous system (CNS) have been profiled for their unesterified sterol content. Using high-performance liquid chromatography (HPLC)-massExpand
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Potential of sterol analysis by liquid chromatography-tandem mass spectrometry for the prenatal diagnosis of Smith-Lemli-Opitz syndrome.
BACKGROUND Smith-Lemli-Opitz syndrome (SLOS), a severe disorder of cholesterol synthesis, is classically diagnosed prenatally by GC-MS analysis of sterols in amniotic fluid. Considering the currentExpand
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