• Publications
  • Influence
Mammalian Sweet Taste Receptors
The sense of taste provides animals with valuable information about the quality and nutritional value of food. Previously, we identified a large family of mammalian taste receptors involved in bitterExpand
  • 926
  • 103
  • PDF
An amino-acid taste receptor
The sense of taste provides animals with valuable information about the nature and quality of food. Mammals can recognize and respond to a diverse repertoire of chemical entities, including sugars,Expand
  • 1,162
  • 86
  • PDF
The Receptors for Mammalian Sweet and Umami Taste
Sweet and umami (the taste of monosodium glutamate) are the main attractive taste modalities in humans. T1Rs are candidate mammalian taste receptors that combine to assemble two heteromericExpand
  • 1,017
  • 80
  • PDF
Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways
Mammals can taste a wide repertoire of chemosensory stimuli. Two unrelated families of receptors (T1Rs and T2Rs) mediate responses to sweet, amino acids, and bitter compounds. Here, we demonstrateExpand
  • 1,029
  • 76
  • PDF
T2Rs Function as Bitter Taste Receptors
Bitter taste perception provides animals with critical protection against ingestion of poisonous compounds. In the accompanying paper, we report the characterization of a large family of putativeExpand
  • 1,142
  • 75
  • PDF
The receptors and cells for mammalian taste
The emerging picture of taste coding at the periphery is one of elegant simplicity. Contrary to what was generally believed, it is now clear that distinct cell types expressing unique receptors areExpand
  • 1,147
  • 66
  • PDF
A Novel Family of Mammalian Taste Receptors
In mammals, taste perception is a major mode of sensory input. We have identified a novel family of 40-80 human and rodent G protein-coupled receptors expressed in subsets of taste receptor cells ofExpand
  • 1,073
  • 62
  • PDF
The cells and logic for mammalian sour taste detection
Mammals taste many compounds yet use a sensory palette consisting of only five basic taste modalities: sweet, bitter, sour, salty and umami (the taste of monosodium glutamate). Although thisExpand
  • 625
  • 49
The Cells and Circuitry for Itch Responses in Mice
The Master Switch for Itch? Recently, gastrin-releasing peptide (GRP) has been implicated as the primary neurotransmitter between itch-sensitive nerve fibers and downstream neurons in the spinalExpand
  • 315
  • 46
  • PDF
Putative Mammalian Taste Receptors A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity
Taste represents a major form of sensory input in the animal kingdom. In mammals, taste perception begins with the recognition of tastant molecules by unknown membrane receptors localized on theExpand
  • 620
  • 32
  • PDF