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Mutagenicity tests of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene.
The mutagenicity of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene was examined in reverse mutation tests, in the chromosomal aberration test with Chinese hamster ovary cells, and in the micronucleus test using mice bone-marrow, finding the increase in polyploidy probably is due to a toxic effect of the compound.
Homology at a possible catalytic site in DNA topoisomerase I.
  • M. Holmstrom
  • Chemistry
    Cell biology international reports
  • 1 November 1988