Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation
EMPA, DAPA and CANA directly inhibit cardiac NHE flux and reduce [Na+]c, possibly by binding with the Na+-binding site of NHE-1, and affect the healthy heart by inducing vasodilation.
Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults.
The effects (benefits and risks) of perioperative intravenous (IV) lidocaine infusion compared to placebo/no treatment or compared to epidural analgesia on postoperative pain and recovery in adults undergoing various surgical procedures are assessed.
Systemic Lidocaine Shortens Length of Hospital Stay After Colorectal Surgery: A Double-blinded, Randomized, Placebo-controlled Trial
Perioperative intravenous lidocaine not only improved gastrointestinal motility but also shortened length of hospital stay significantly, and may provide a convenient and inexpensive approach to improve outcome for patients not suitable for epidural anesthesia.
Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery.
Evidence of effect for intravenous lidocaine on the reduction of postoperative pain is found at 'early time points' in participants undergoing laparoscopic abdominal surgery and at 'intermediate time points (24 hours)' after surgery, but no evidence of effect was found for lidocane to reduce pain at 'late time points '(48 hours) after surgery.
Failed epidural: causes and management.
The use of patient-controlled epidural analgesia with background infusion with addition of adjuvants, especially opioids and epinephrine, may be the best method for postoperative analgesia.
Apoptosis induction by different local anaesthetics in a neuroblastoma cell line.
All commonly used local anaesthetics induce neuronal apoptosis in clinically used concentrations and the neurotoxicity correlates with lipid solubility and thus with the conduction blocking potency of the local anaesthetic, but is independent of the chemical class (ester/amide).
Noninvasive Continuous Arterial Blood Pressure Monitoring with Nexfin®
Arterial blood pressure can be measured noninvasively and continuously using physiologic pressure reconstruction and values are comparable to invasive monitoring.
Magnesium—Essentials for Anesthesiologists
An overview of current knowledge and available evidence with respect to physiologic aspects of magnesium and proposed indications and recommendations for its use in the clinical setting is provided.
Value of Single-Injection or Continuous Sciatic Nerve Block in Addition to a Continuous Femoral Nerve Block in Patients Undergoing Total Knee Arthroplasty: A Prospective, Randomized, Controlled Trial
- J. Wegener, B. van Ooij, C. V. van Dijk, M. Hollmann, B. Preckel, M. Stevens
- MedicineRegional anesthesia and pain medicine
- 11 May 2011
A single-injection or continuous sciatic nerve block in addition to a femoral nerve block did not influence time-to-discharge readiness, and a single- injection can reduce severe pain on the day of the surgery, whereas a continuous nerve block reduces moderate pain during mobilization on the first 2 postoperative days.
Chronic Hiccups: An Underestimated Problem
When managing hiccup patients within the clinical routine, it is of importance to conduct a comprehensive and effective diagnostic workup; a well-functioning interdisciplinary team is needed to address possible causes for the symptom.