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Roary: rapid large-scale prokaryote pan genome analysis
TLDR
Roary, a tool that rapidly builds large-scale pan genomes, identifying the core and accessory genes, is introduced, making construction of the pan genome of thousands of prokaryote samples possible on a standard desktop without compromising on the accuracy of results. Expand
Genome sequence of Yersinia pestis, the causative agent of plague
TLDR
The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve. Expand
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
TLDR
The genome sequence is sequenced of a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands. Expand
Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica
TLDR
The authors' analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions. Expand
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.
TLDR
The crucial role that accessory elements play in the rapid evolution of S. aureus is clearly illustrated by comparing the MSSA476 genome with that of an extremely closely related MRSA community-acquired strain; the differential distribution of large mobile elements carrying virulence and drug-resistance determinants may be responsible for the clinically important phenotypic differences in these strains. Expand
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.
TLDR
It is proposed that variable horizontal gene acquisition by B. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species. Expand
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the genome consistsExpand
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study
TLDR
The discovery of a strain of S aureus isolated from bulk milk that was phenotypically resistant to meticillin but tested negative for the mecA gene is reported and new diagnostic guidelines for the detection of MRSA should consider the inclusion of tests for mecALGA251. Expand
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
TLDR
The J2315 genome contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen, and Pseudogenes in virulence determinants suggest that the pathogenic response of J 2315 may have been recently selected to promote persistence in the CF lung. Expand
Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors.
TLDR
The genome sequence of a plant pathogenic enterobacterium, Erwinia carotovora subsp. Expand
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