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Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products.
TLDR
The hypothesis that synthesis of pdFVIII under physiological conditions could result in reduced heterogeneity and/or subtle differences in structure/conformation which, in turn, may result in reducing FVIII proteolytic processing relative to FL-rFV III is supported. Expand
Siloxy Titanocene and Zirconocene Complexes Derived from the Ferriomethyl-Silanol Cp(OC)2Fe−CH2−SiMe2OH: Synthesis and Structure of Cp(OC)2Fe−CH2−SiMe2O−M(Cl)Cp2 (M = Ti, Zr) and
The Et3N-assisted condensation of the ferriomethyl-silanol Cp(OC)2Fe−CH2−SiMe2OH (1) with 1 equiv of Cp2MCl2 (M = Ti (2a), Zr (2b)) leads to the formation of the iron fragment substitutedExpand
Mechanism of olefin hydrosilylation catalyzed by ruCI2(CO)2(PPh3)2
Density functional theory (DFT) was used to explore the different mechanistic possibilities for the hydrosilylation reaction between methyldimethoxysilane and methylvinyldimethoxysilane catalyzed byExpand
Mechanism of olefin hydrosilylation catalyzed by [RuCl(NCCH3)5]+: A DFT study
Density functional theory (DFT) was used to explore the different mechanistic possibilities for the hydrosilylation reaction between methyldimethoxysilane and methylvinyldimethoxysilane catalyzed byExpand
Ruthenium based catalysts for olefin hydrosilylation: dichloro(p-cymene)ruthenium and related complexes.
TLDR
The original catalyst (B1) appears to strike an optimum balance with regard to the sigma-donor capabilities of the ligands as it is able to interconvert relatively freely between the Ru(II) and Ru(IV) oxidation states. Expand
Reactions of poly-hexafluoropropylene oxide acids and their corresponding salts
Abstract Investigation of the decomposition or fluorination of poly-hexafluoropropylene oxide (poly-HFPO) carboxylic acids and their salts reveals a new type of product from the decarboxylation ofExpand
Tungstenmethyl-Dimethylsilanols Cp(Oc)2(R3P)W—CH2—SiMe2OH (R = Me, Ph) – Synthesis Via Oxygenation or Hydrolysis
Abstract The tungstenmethyl-dimethylsilanols Cp(OC)2(R3P)W-CH2-SiMe2OH [R = Me (6a), Ph (6b)] have been synthesized by oxofunctionalization of the tungstenmethyl-silanes Cp(OC)2(R3P)W- CH2-SiMe2H [RExpand
Profiling and Comparing the Immunogenicity of a Novel Single-Chain FVIII Molecule (rVIII-SingleChain) for the Treatment of Hemophilia a
TLDR
The immunogenicity of rVIII-SingleChain has been extensively characterized in PTPs over 28,418 exposure days equivalent to more than 233 treatment years and all available data support the hypothesis that the unique attributes of this single-chain molecule may translate into reduced Immunogenicity when used for used for therapy in patients with hemophilia A. Expand
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