M. Hoffman

Publications53
h-index26
Citations2,598
Highly Influential Citations64
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Preparation and characterization of nanoparticles containing an antihypertensive agent.
Isradipine, an antihypertensive agent, was encapsulated by the nanoprecipitation method using polymers including poly(epsilon-caprolactone), poly(D,L-lactide) and poly(d, L-lactide-co-glycolide). In… Expand
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Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique.
The preparation of nanoparticles (NP) as an improved colloidal carrier system for proteins was investigated. Bovine serum albumin (BSA) was used as model drug. Owing to the high solubility of the… Expand
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The preparation and evaluation of poly(ϵ-caprolactone) microparticles containing both a lipophilic and a hydrophilic drug
An original dosage form for oral delivery based on the encapsulation of both, lipophilic and hydrophilic drugs, in poly(epsilon-caprolactone) (PCL) microparticles prepared either by the oil-in-water… Expand
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Antiglaucomatous activity of betaxolol chlorhydrate sorbed onto different isobutylcyanoacrylate nanoparticle preparations
Abstract The objectives of the present work were to evaluate the effects, on the reduction of the intra-ocular pressure (IOP) in glaucomatous rabbits, of different physico-chemical parameters such… Expand
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Effect of the microencapsulation of nanoparticles on the reduction of burst release.
The initial burst release is one of the major problems in the development of controlled release formulations including drug-loaded micro- and nanoparticles, especially with low molecular weight… Expand
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Non-degradable microparticles containing a hydrophilic and/or a lipophilic drug: preparation, characterization and drug release modeling.
Non-degradable microparticles based on ammonio methacrylate copolymers (Eudragit RS:RL 4:1 blends) containing the hydrophilic drug propranolol HCl and/or the lipophilic drug nifedipine were prepared… Expand
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In Vitro and In Vivo Evaluation of Oral Heparin–Loaded Polymeric Nanoparticles in Rabbits
Background—Owing to its short half-life and lack of oral absorption, heparin has to be administered by the parenteral route. An oral heparin formulation, however, would avoid the disadvantages of… Expand
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Oral evaluation in rabbits of cyclosporin-loaded Eudragit RS or RL nanoparticles.
The hydrophobic cyclic undecapeptide cyclosporin A (CyA) used in the prevention of graft rejection and in the treatment of autoimmune diseases was encapsulated by nanoprecipitation within… Expand
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Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study.
The water-in-oil-in-water (w/o/w) emulsification process is the method of choice for the encapsulation inside polymeric particles of hydrophilic drugs such as proteins and peptides which are high… Expand
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Lymphatic Targeting of Polymeric Nanoparticles After Intraperitoneal Administration in Rats
Following intraperitoneal administration, the lymphatic targeting of polyacrylic nanoparticles has been evaluated in thoracic duct cannulated rats. The dosage forms administered consisted of… Expand
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