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Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.
Genomic analysis of brain metastases provides an opportunity to identify potentially clinically informative alterations not detected in clinically sampled primary tumors, regional lymph nodes, or extracranial metastases, suggesting that sequencing of primary biopsies alone may miss a substantial number of opportunities for targeted therapy. Expand
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas
Using whole-exome sequencing, mutations in CTNNB1 (β-catenin) and BRAF were identified in nearly all adamantinomatous and papillary craniopharyngiomas examined and clonal in each tumor subtype, and these findings have important implications for the diagnosis and treatment of these neoplasms. Expand
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair / fair skin background
People with pale skin, red hair, freckles and an inability to tan—the ‘red hair/fair skin’ phenotype—are at highest risk of developing melanoma, compared to all other pigmentation types. Genetically,Expand
Composite angioimmunoblastic T-cell lymphoma and diffuse large B-cell lymphoma: a case report and review of the literature.
Findings raise the possibility that the EBV-associated large B-cell lymphoma is a secondary event in AILT via EBV infection or reactivation followed by clonal expansion of an immortalizedEBV-infected B cell clone. Expand
Oncocytic Adrenocortical Carcinoma: A Morphologic, Immunohistochemical and Ultrastructural Study of Four Cases
Clinical, histologic, immunohistochemical, and ultrastructural findings of four cases of non-functioning oncocytic adrenocortical carcinomas, including large tumor size, extracapsular extension, blood vessel invasion, necrosis, and metastasis are presented. Expand
HER-2/neu gene amplification compared with HER-2/neu protein overexpression and interobserver reproducibility in invasive breast carcinoma.
Positive membranous staining, especially 2+, did not predict gene amplification and the low interobserver reproducibility in separating 2+ from 3+ cases necessitates further confirmation by FISH before treatment decisions are made. Expand
A UV-independent pathway to melanoma carcinogenesis in the redhair-fairskin background
The data suggest that the pheomelanin pigment pathway produces ultraviolet-radiation-independent carcinogenic contributions to melanomagenesis by a mechanism of oxidative damage, which suggests protection from ultraviolet radiation remains important, and additional strategies may be required for optimal melanoma prevention. Expand
Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.
The ability to interrogate ex vivo response to PD-1 blockade using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS) is demonstrated, which represents a novel platform to evaluate ICB using established murine models as well as clinically relevant patient specimens. Expand
Activation of PI3K Signaling in Merkel Cell Carcinoma
PI3K pathway activation may drive tumorigenesis in a subset of MCC and screening these tumors for PIK3CA mutations could help identify patients who may respond to treatment with PI3K pathways inhibitors, under active clinical development. Expand
Malignant stromal tumor of the gallbladder with interstitial cells of Cajal phenotype.
This case demonstrates that a malignant stromal tumor that is histologically and immunohistochemically identical to gastrointestinal stronal tumor can occur in the gallbladder, and that the expression of CD117 may be of therapeutic importance. Expand