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Hair Cells Require Phosphatidylinositol 4,5-Bisphosphate for Mechanical Transduction and Adaptation
After opening in response to mechanical stimuli, hair cell transduction channels adapt with fast and slow mechanisms that each depend on Ca(2+). We demonstrate here that transduction and adaptationExpand
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Fast Adaptation in Vestibular Hair Cells Requires Myosin-1c Activity
In sensory hair cells of the inner ear, mechanical amplification of small stimuli requires fast adaptation, the rapid closing of mechanically activated transduction channels. In frog and mouseExpand
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Phospholipase C-independent group I metabotropic glutamate receptor-mediated inward current in mouse purkinje cells.
The mGluR agonist 1S,3R-ACPD induces a potent excitatory inward current in various central neurons, but the underlying mechanism is not fully understood. Thus, we explored the signal transductionExpand
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Cerebellar Globular Cells Receive Monoaminergic Excitation and Monosynaptic Inhibition from Purkinje Cells
Inhibitory interneurons in the cerebellar granular layer are more heterogeneous than traditionally depicted. In contrast to Golgi cells, which are ubiquitously distributed in the granular layer,Expand
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Impaired delay but normal trace eyeblink conditioning in PLCβ4 mutant mice
To elucidate the functional role of phospholipase Cβ4 (PLCβ4), which is highly expressed in the Purkinje cells of the rostral cerebellum, cerebellar long-term depression (LTD) and delay and traceExpand
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Localization of phospholipase Cbeta isozymes in the mouse cerebellum.
To elucidate the role of phospholipase Cbeta (PLCbeta) isozymes in the cerebellum, the distributions of PLCbeta3 and PLCbeta4 were examined in wild-type and PLCbeta4-deficient mutant mice usingExpand
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Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells.
Activation of the type-1 metabotropic glutamate receptor (mGluR1) signaling pathway in the cerebellum involves activation of phospholipase C (PLC) and protein kinase C (PKC) for the induction ofExpand
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Phospholipase Cβ4 and Protein Kinase Cα and/or Protein Kinase CβI Are Involved in the Induction of Long Term Depression in Cerebellar Purkinje Cells*
Activation of the type-1 metabotropic glutamate receptor (mGluR1) signaling pathway in the cerebellum involves activation of phospholipase C (PLC) and protein kinase C (PKC) for the induction ofExpand
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Role of Ca2+-ATPase in spontaneous oscillations of cytosolic free Ca2+in GH3rat pituitary cells
Abstract The relative contribution of voltage-sensitive Ca 2+ channels, Ca 2+ -ATPases, and Ca 2+ release from intracellular stores to spontaneous oscillations in cytosolic free Ca 2+ concentrationExpand
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Are Involved in the Induction of Long Term Depression in Cerebellar Purkinje Cells *
From the ‡Department of Molecular Neurobiology, Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, the ¶Department of MolecularExpand
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